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dc.contributor.authorMartins de Sousa, K.-
dc.contributor.authorLinklater, D.P.-
dc.contributor.authorMurdoch, B.J.-
dc.contributor.authorAl Kobaisi, M.-
dc.contributor.authorCrawford, R.J.-
dc.contributor.authorJudge, R.-
dc.contributor.authorDashper, S.-
dc.contributor.authorSloan, A.J.-
dc.contributor.authorLosic, D.-
dc.contributor.authorIvanova, E.P.-
dc.identifier.citationACS Applied Bio Materials, 2023; 6(3):1054-1070-
dc.description.abstractDespite recent advances in the development of orthopedic devices, implant-related failures that occur as a result of poor osseointegration and nosocomial infection are frequent. In this study, we developed a multiscale titanium (Ti) surface topography that promotes both osteogenic and mechano-bactericidal activity using a simple two-step fabrication approach. The response of MG-63 osteoblast-like cells and antibacterial activity toward Pseudomonas aeruginosa and Staphylococcus aureus bacteria was compared for two distinct micronanoarchitectures of differing surface roughness created by acid etching, using either hydrochloric acid (HCl) or sulfuric acid (H2SO4), followed by hydrothermal treatment, henceforth referred to as either MN-HCl or MN-H2SO4. The MN-HCl surfaces were characterized by an average surface microroughness (Sa) of 0.8 ± 0.1 μm covered by blade-like nanosheets of 10 ± 2.1 nm thickness, whereas the MN-H2SO4 surfaces exhibited a greater Sa value of 5.8 ± 0.6 μm, with a network of nanosheets of 20 ± 2.6 nm thickness. Both micronanostructured surfaces promoted enhanced MG-63 attachment and differentiation; however, cell proliferation was only significantly increased on MN-HCl surfaces. In addition, the MN-HCl surface exhibited increased levels of bactericidal activity, with only 0.6% of the P. aeruginosa cells and approximately 5% S. aureus cells remaining viable after 24 h when compared to control surfaces. Thus, we propose the modulation of surface roughness and architecture on the micro- and nanoscale to achieve efficient manipulation of osteogenic cell response combined with mechanical antibacterial activity. The outcomes of this study provide significant insight into the further development of advanced multifunctional orthopedic implant surfaces.-
dc.description.statementofresponsibilityKarolinne Martins de Sousa, Denver P. Linklater, Billy J. Murdoch, Mohammad Al Kobaisi, Russell J. Crawford, Roy Judge, Stuart Dashper, Alastair J. Sloan, Dusan Losic, and Elena P. Ivanova-
dc.publisherAmerican Chemical Society-
dc.rights© 2023 American Chemical Society-
dc.subjectantibacterial surfaces-
dc.subjectbone-titanium integration-
dc.subjecthierarchical micronanotopography-
dc.subjectmechano-bactericidal surfaces-
dc.subjectsurface engineering-
dc.subject.meshStaphylococcus aureus-
dc.subject.meshAnti-Bacterial Agents-
dc.subject.meshSurface Properties-
dc.titleModulation of MG-63 Osteogenic Response on Mechano-Bactericidal Micronanostructured Titanium Surfaces.-
dc.typeJournal article-
pubs.publication-statusPublished online-
dc.identifier.orcidLosic, D. [0000-0002-1930-072X]-
Appears in Collections:Chemical Engineering publications

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