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Type: Journal article
Title: Induction of the CD1a Langerhans cell marker on human monocytes
Author: Athanasas-Platsis, S.
Savage, N.
Winning, T.
Walsh, L.
Citation: Archives of Oral Biology, 1995; 40(2):157-160
Publisher: Pergamon Press
Issue Date: 1995
ISSN: 0003-9969
Statement of
Athanasas-Platsis, S. ; Savage, N.W. ; Winning, T.A. ; Walsh, L.J.
Abstract: Monocytes have recently been recognized as a precursor of Langerhans cells. This study examined the regulatory influence of the epithelial environment on the putative first step of the transition towards a Langerhans cell phenotype--the induction of CD1a antigen. The keratinocyte-derived cytokines granulocyte-macrophage-colony-stimulating factor, tumour necrosis factor-alpha, interleukin-6, and interleukin-1 beta induced CD1a expression, as did supernatants of keratinocytes extracted from inflammatory sites (periodontitis). Induction was abrogated by transforming growth factor-beta and a keratinocyte-derived interleukin-1 inhibitor. The optimal temperature for induction was 34 degrees C, not 37 degrees C. These results demonstrate that the components of the epithelial environment (cytokines and lower temperature) exert important influences, which may be part of local regulation of Langerhans cell development.
Keywords: monocytes; Langerhans cells; differentiation; cytokines
RMID: 0030003001
DOI: 10.1016/0003-9969(94)00152-2
Appears in Collections:Dentistry publications

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