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Type: Journal article
Title: Health-related quality of life in patients with melanoma brain metastases treated with immunotherapy.
Author: Thompson, J.R.
Lai-Kwon, J.
Morton, R.L.
Guminski, A.D.
Gonzalez, M.
Atkinson, V.
Sandhu, S.
Brown, M.P.
Menzies, A.M.
McArthur, G.A.
Lo, S.N.
Long, G.V.
Bartula, I.
Citation: Immunotherapy, 2023; 15(8):593-610
Publisher: Future Medicine Ltd
Issue Date: 2023
ISSN: 1750-743X
Statement of
Jake R Thompson, Julia Lai-Kwon, Rachael L Morton, Alexander D Guminski, Maria Gonzalez, Victoria Atkinson, Shahneen Sandhu, Michael P Brown, Alexander M Menzies, Grant A McArthur, Serigne N Lo, Georgina V Long, Iris Bartula
Abstract: Aims: To describe the health-related quality of life (HRQoL) of melanoma brain metastasis (MBM) patients throughout the first 18 weeks of ipilimumab-nivolumab or nivolumab treatment. Materials & methods: HRQoL data (European Organisation for Research and Treatment of Cancer's Core Quality of Life Questionnaire, additional Brain Neoplasm Module, and EuroQol 5-Dimension 5-Level Questionnaire) were collected as a secondary outcome of the Anti-PD1 Brain Collaboration phase II trial. Mixed linear modeling assessed changes over time, whereas the Kaplan-Meier method was used to determine median time to first deterioration. Results: Asymptomatic MBM patients treated with ipilimumab-nivolumab (n = 33) or nivolumab (n = 24) maintained baseline HRQoL. MBM patients with symptoms or leptomeningeal/progressive disease treated with nivolumab (n = 14) reported a statistically significant trend toward improvement. Conclusion: MBM patients treated with either ipilimumab-nivolumab or nivolumab did not report a significant deterioration in HRQoL within 18 weeks of treatment initiation. Clinical trial registration: NCT02374242 (
Keywords: HRQoL
brain metastases
Rights: Copyright status unknown
DOI: 10.2217/imt-2022-0262
Appears in Collections:Medicine publications

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