Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Incident atrial fibrillation in relation to ventilatory parameters: a prospective cohort study.
Author: Noubiap, J.J.
Tu, S.J.
Emami, M.
Middeldorp, M.E.
Elliott, A.D.
Sanders, P.
Citation: Canadian Journal of Cardiology, 2023; 39(5):614-622
Publisher: Elsevier BV
Issue Date: 2023
ISSN: 0828-282X
Statement of
Jean Jacques Noubiap, Samuel J. Tu, Mehrdad Emami, Melissa E. Middeldorp, Adrian D. Elliott, Prashanthan Sanders
Abstract: BACKGROUND: There is a paucity of data on the association between respiratory function and atrial fibrillation (AF). This study aimed to assess the relationship between forced expiratory volume (FEV1), forced vital capacity (FVC), and FEV1/FVC and incident AF. METHODS: We performed an analysis of prospectively collected data from the UK Biobank. We included all participants with available spirometry and excluded those with a prior AF. Incident AF was ascertained through hospitalization and death records, and dose-response associations were assessed using multivariable Cox regression analysis with adjustment for known AF risk factors. RESULTS: We studied 348,219 white individuals (54.1% female) with a median age of 58.1 (IQR 50.8-63.5) years. Over a median follow-up time of 11.5 years (IQR: 11.0-12.6 years), a total of 18,188 incident AF events occurred. After standardization to sex, age, and height, the risk of AF consistently increased with decreasing FEV1 percentage predicted, FEV1 z-score, and FVC z-score. The risk of AF linearly increased with decreasing FEV1/FVC ratio, and those that had airway obstruction as defined by an FEV1/FVC ratio < 0.70 had a 23% greater risk of incident AF (aHR 1.23, 95% CI 1.19-1.28) compared to those without airway obstruction. Patients with known chronic obstructive pulmonary disease and asthma were at 40% (aHR 1.40, 95% CI 1.29-1.51) and 17% (aHR 1.17, 95% CI 1.12-1.22) increased risk of incident AF. CONCLUSION: These findings indicate that reduced ventilatory function is associated with increased risk of AF independently of age, sex, smoking, and other known AF risk factors.
Keywords: Atrial fibrillation
chronic obstructive pulmonary disease
forced expiratory volume
vital capacity
Rights: Crown Copyright © 2023 Published by Elsevier Inc. on behalf of the Canadian Cardiovascular Society. All rights reserved.
DOI: 10.1016/j.cjca.2023.02.004
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.