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https://hdl.handle.net/2440/1390
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Type: | Journal article |
Title: | Modulation by presynaptic β-adrenoceptors of noradrenaline release from sympathetic nerves in human dental pulp |
Other Titles: | Modulation by presynaptic beta-adrenoceptors of noradrenaline release from sympathetic nerves in human dental pulp |
Author: | Parker, D. Marino, V. Ivar, P. de la Lande, I. |
Citation: | Archives of Oral Biology, 1998; 43(12):949-954 |
Publisher: | Pergamon |
Issue Date: | 1998 |
ISSN: | 0003-9969 1879-1506 |
Statement of Responsibility: | D.A.S Parker, V Marino, P.M Ivar, I.S de la Lande |
Abstract: | This study was undertaken to test for the presence of presynaptic beta-adrenoceptors on sympathetic nerves in human dental pulp and, if present, to investigate the subtype. Pulp was excised from freshly extracted teeth, incubated with [3H]-noradrenaline (0.6 micromol/l) and subsequently superfused with Krebs solution. Sympathetic nerves were stimulated at 5 Hz for 100 sec. The non-specific beta-adrenoceptor agonist isoprenaline (1.0 micromol/l), and the selective beta2-agonist salbutamol (10 micromol/l) facilitated the release of [3H]-noradrenaline; isoprenaline, but not salbutamol, also facilitated this release in the presence of desipramine (DMI, 0.3 micromol/l), corticosterone (10 micromol/l) and rauwolscine (0.1 micromol/l). BRL 37344 (1.0 micromol/l), a beta3-agonist, had no effect on [3H]-noradrenaline release. The facilitatory effects of isoprenaline and salbutamol were inhibited by the non-specific beta-antagonist propranolol (1.0 micromol/l), while that of salbutamol was inhibited in the presence of ICI-188,551 (1.0 micromol/l), a selective beta2-antagonist, as well. The beta1-antagonist atenolol (1.0 micromol/l) potentiated the facilitatory effects of isoprenaline in the presence of DMI and corticosterone. Neither propranolol nor ICI-188,551 alone affected the release of [3H]-noradrenaline. These results establish the presence of presynaptic beta-adrenoceptors on sympathetic nerves in human dental pulp. It is suggested that they are of the beta2-subtype, although a greater range of agonists and antagonists needs to be used to clarify the nature of the the beta-adrenoceptors. |
Keywords: | Human dental pulp sympathetic nerves presynaptic β-receptors isoprenaline propranolol salbutamol atenolol |
Rights: | © 1998 Elsevier Science Ltd. All rights reserved. |
DOI: | 10.1016/S0003-9969(98)00087-9 |
Published version: | http://dx.doi.org/10.1016/s0003-9969(98)00087-9 |
Appears in Collections: | Aurora harvest 2 Dentistry publications |
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