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|Title:||Modulation by presynaptic β-adrenoceptors of noradrenaline release from sympathetic nerves in human dental pulp|
|Other Titles:||Modulation by presynaptic beta-adrenoceptors of noradrenaline release from sympathetic nerves in human dental pulp|
de la Lande, I.
|Citation:||Archives of Oral Biology, 1998; 43(12):949-954|
|D.A.S Parker, V Marino, P.M Ivar, I.S de la Lande|
|Abstract:||This study was undertaken to test for the presence of presynaptic beta-adrenoceptors on sympathetic nerves in human dental pulp and, if present, to investigate the subtype. Pulp was excised from freshly extracted teeth, incubated with [3H]-noradrenaline (0.6 micromol/l) and subsequently superfused with Krebs solution. Sympathetic nerves were stimulated at 5 Hz for 100 sec. The non-specific beta-adrenoceptor agonist isoprenaline (1.0 micromol/l), and the selective beta2-agonist salbutamol (10 micromol/l) facilitated the release of [3H]-noradrenaline; isoprenaline, but not salbutamol, also facilitated this release in the presence of desipramine (DMI, 0.3 micromol/l), corticosterone (10 micromol/l) and rauwolscine (0.1 micromol/l). BRL 37344 (1.0 micromol/l), a beta3-agonist, had no effect on [3H]-noradrenaline release. The facilitatory effects of isoprenaline and salbutamol were inhibited by the non-specific beta-antagonist propranolol (1.0 micromol/l), while that of salbutamol was inhibited in the presence of ICI-188,551 (1.0 micromol/l), a selective beta2-antagonist, as well. The beta1-antagonist atenolol (1.0 micromol/l) potentiated the facilitatory effects of isoprenaline in the presence of DMI and corticosterone. Neither propranolol nor ICI-188,551 alone affected the release of [3H]-noradrenaline. These results establish the presence of presynaptic beta-adrenoceptors on sympathetic nerves in human dental pulp. It is suggested that they are of the beta2-subtype, although a greater range of agonists and antagonists needs to be used to clarify the nature of the the beta-adrenoceptors.|
|Keywords:||Human dental pulp; sympathetic nerves; presynaptic β-receptors; isoprenaline; propranolol; salbutamol; atenolol|
|Rights:||© 1998 Elsevier Science Ltd. All rights reserved.|
|Appears in Collections:||Dentistry publications|
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