Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/14318
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Naloxone and its quaternary derivative, naloxone methiodide, have differing affinities for m, d, k and opiod receptors in mouse brain homogenates |
Author: | Lewanowitsch, T. Irvine, R. |
Citation: | Brain Research, 2003; 964(2):302-305 |
Publisher: | Elsevier Science Bv |
Issue Date: | 2003 |
ISSN: | 0006-8993 1872-6240 |
Statement of Responsibility: | Tanya Lewanowitsch and Rodney James Irvine |
Abstract: | Naloxone and naloxone methiodide both act on opioid receptors but naloxone methiodide has limited access to the brain. Naloxone methiodide has been shown to have a lower affinity for opioid receptors than naloxone in the rat and guinea pig but has not been tested in the mouse. We aimed to investigate this by using [3H]DAMGO, [3H]DPDPE and [3H]U-69,593 to compare the ability of naloxone and naloxone methiodide to displace binding to μ, δ and κ opioid receptors in mouse brain homogenates. Significant binding was observed for each receptor type and the binding affinity for naloxone versus naloxone methiodide was found to be 15:1 for μ, 6:1 for κ and 330:1 for δ receptors. Therefore, naloxone methiodide does have a lower affinity for opioid receptors than naloxone in mouse brain tissue, which must be taken into consideration in experimental designs. |
Keywords: | Naloxone Naloxone methiodide Opioid receptor mouse |
Description: | Copyright © 2002 Elsevier Science B.V. All rights reserved. |
DOI: | 10.1016/S0006-8993(02)04117-3 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/506048/description#description |
Published version: | http://dx.doi.org/10.1016/s0006-8993(02)04117-3 |
Appears in Collections: | Aurora harvest 7 Pharmacology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.