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Type: Journal article
Title: Comparison of tincture of opium and methadone to control opioid withdrawal in a Thai treatment centre
Author: Jittiwutikarn, J.
Ali, R.
White, J.
Bochner, F.
Somogyi, A.
Foster, D.
Citation: British Journal of Clinical Pharmacology, 2004; 58(5):536-541
Publisher: Blackwell Publishing Ltd
Issue Date: 2004
ISSN: 0306-5251
Statement of
Jaroon Jittiwutikarn, Robert Ali, Jason M. White, Felix Bochner, Andrew A. Somogyi and David J. R. Foster
Abstract: AIMS: To evaluate the effectiveness of oral tincture of opium (TOP) and methadone to control opioid withdrawal in patients in northern Thailand. METHODS: Open label, parallel group study in an inpatient facility compared 15 former heroin users receiving methadone 5–20 mg 12 hourly with 15 former opium smokers receiving TOP (3.33–10 mg morphine equivalents 12 hourly). At 0, 1, 3 and 8 h, blood, withdrawal scores and subjective opioid effects were collected. RESULTS: There was a reciprocal association between withdrawal scores/direct subjective opioid effects and plasma (R)-methadone, but not plasma morphine, concentrations. Withdrawal scores at the time of dosing were higher in the TOP patients (9.1 ± 3) than in the methadone patients (4.5 ± 4.6) and in the TOP patients were significantly (P = 0.001) attenuated at 3 and 8 h. CONCLUSIONS: At the doses used, TOP was inferior to methadone in suppressing withdrawal. It could prove to be a cost effective and valuable drug, but only after dose size and frequency are further investigated.
Keywords: Humans; Opioid-Related Disorders; Substance Withdrawal Syndrome; Methadone; Opium; Morphine; Narcotics; Administration, Oral; Adult; Middle Aged
Description: The definitive version is available at
RMID: 0020041048
DOI: 10.1111/j.1365-2125.2004.02209.x
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Appears in Collections:Pharmacology publications

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