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Type: Journal article
Title: Use of radiotelemetry to evaluate respiratory depression produced by chronic methadone administration
Author: Lewanowitsch, T.
White, J.
Irvine, R.
Citation: European Journal of Pharmacology, 2004; 484(2-3):303-310
Publisher: Elsevier Science BV
Issue Date: 2004
ISSN: 0014-2999
Statement of
Tanya Lewanowitsch, Jason M. White and Rodney J. Irvine
Abstract: Illicit and therapeutic opioid administration can result in overdose due to opioid-induced respiratory depression. Research investigating the respiratory depressant effects of opioids has been limited due to difficulties associated with acquiring long-term respiratory data. This study examined the novel use of radiotelemetry to measure respiratory rate, heart rate, locomotor activity and blood pressure in rats treated chronically with methadone. Over 4 days of treatment, respiratory rate decreased, but partial tolerance appeared to develop during active (night) periods. Decreased heart rate was observed during the night periods and tolerance appeared to develop to this effect. Activity and blood pressure did not change with treatment. The effects of naloxone hydrochloride and naloxone methiodide administration on the methadone-treated rats were also examined and both antagonists increased respiratory rate and heart rate, with only naloxone hydrochloride producing significant increases in activity. Radiotelemetry offers a means of evaluating drug effects on respiratory rate continually in ambulatory, unstressed animals.
Keywords: Methadone; respiratory depression; Naloxone methiodide; radiotelemetry
Description: Copyright © 2003 Elsevier B.V. All rights reserved.
RMID: 0020040052
DOI: 10.1016/j.ejphar.2003.11.025
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Appears in Collections:Pharmacology publications

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