Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14480
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Type: Journal article
Title: Absorption of morphine from a slow-release emulsion used to induce morphine dependence in rats.
Author: Salem, A.
Hope, W.
Citation: Journal of Pharmacological and Toxicological Methods, 1999; 40(3):159-164
Publisher: ELSEVIER SCIENCE INC
Issue Date: 1999
ISSN: 1056-8719
1873-488X
Abstract: This study was performed to measure absorption of morphine from the injection site following treatment of rats with slow-release emulsions formulated with morphine hydrochloride and morphine base. Samples of emulsion were collected from the injection site of halothane anesthetized animals at 24 and 48 h following emulsion treatment and concentrations of morphine remaining in the emulsion were analyzed using high-performance liquid chromatography (HPLC). In another group of morphine-treated rats, at times equivalent to collecting samples of emulsion, the intensity of naloxone-precipitated withdrawal behaviors was monitored. Both morphine base- and hydrochloride-containing emulsions induced a high degree of physical dependence in animals treated over 48 h. Release of morphine from emulsions containing morphine base was slower than that from the hydrochloride formulations. In the 24-h morphine base-treated animals, approximately 45% was absorbed from the injection site as opposed to 99% in the 24-h morphine hydrochloride-treated animals. These results suggest that morphine base containing emulsions provide a more sustained exposure to the opioid.
Keywords: Feces; Animals; Rats; Rats, Wistar; Morphine Dependence; Body Weight; Morphine; Emulsions; Delayed-Action Preparations; Chromatography, High Pressure Liquid; Administration, Cutaneous; Female
RMID: 0030003391
DOI: 10.1016/S1056-8719(98)00050-1
Appears in Collections:Pharmacology publications

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