Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/14499
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Type: Journal article
Title: Attenuation of morphine withdrawal signs by the GABAB receptor agonist baclofen
Author: Bexis, S.
Ong, J.
White, J.
Citation: Life Sciences, 2001; 70(4):395-401
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2001
ISSN: 0024-3205
1879-0631
Statement of
Responsibility: 
Sotiria Bexis, Jennifer Ong and Jason White
Abstract: Abstract The present study examined the effect of the γ-aminobutyric acidB (GABAB) receptor agonist, baclofen on naloxone-induced withdrawal signs in morphine-dependent rats and modification by the antagonist, 3-aminopropyl-cyclohexylmethylphosphinic acid (CGP 46381). Morphine was administered via mini-osmotic pumps for 7 days to induce physical dependence. Baclofen (20 mg kg−1) decreased stereotyped head movements, chewing, chatter, ptosis and body weight loss, induced by naloxone (10 mg kg−1) in morphine-dependent rats. CGP 46381 (20 mg kg−1) reversed the effects exerted by baclofen on stereotyped head movements, ptosis, and weight loss and partially reversed the effect of baclofen on chewing. It can be concluded that baclofen has some potential in the treatment of opioid withdrawal and that GABAB receptors may be implicated in such a withdrawal.
Keywords: Baclofen; Morphine-dependence; Morphine withdrawal; rat; Naloxone; CGP 46381
RMID: 0020011367
DOI: 10.1016/S0024-3205(01)01485-0
Description (link): http://www.elsevier.com/wps/find/journaldescription.cws_home/525477/description#description
Appears in Collections:Pharmacology publications

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