Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/1472
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dc.contributor.authorIshimaru, J.en
dc.contributor.authorOguma, Y.en
dc.contributor.authorGoss, A.en
dc.date.issued2000en
dc.identifier.citationBritish Journal of Oral & Maxillofacial Surgery, 2000; 38(4):354-359en
dc.identifier.issn0266-4356en
dc.identifier.issn1532-1940en
dc.identifier.urihttp://hdl.handle.net/2440/1472-
dc.description.abstractWe measured matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMP) in temporomandibular joint (TMJ) disorders. All patients were fully investigated, by visual analogue pain scores, plain radiographs and double-contrast arthrotomograms. The patients were grouped according to whether or not they were in pain. There were 35 patients with painful joints; 16 painless crepitating joints and 10 with chronic closed locked joints. A further group of 9 volunteers with no symptoms of TMJ abnormalities were used as controls. We found that synovial fluid concentration of MMP-3 was significantly increased (1117.2 (164.0) ng/ml) (P< 0.05) in the painful group compared with controls (436.2 (94.8) ng/ml) and with the two groups with painless TMJ (475.0 (113. 0) ng/ml/crepitation, and 516.0 (115.1) ng/ml/closed locked joints). MMP-1 and TIMP-1 were not recordable in most joints, and the serum concentrations of MMP-1, MMP-3, and TIMP-1 were similar to those in controls in all groups. There was no correlationship between MMP-3 concentration and joint morphology as shown by plain radiographs and double contrast arthrotomograms. These findings indicate that the synovia of painful joints are inflamed.en
dc.language.isoenen
dc.publisherChurchill Livingstoneen
dc.subjectSynovial Fluid; Humans; Temporomandibular Joint Disorders; Synovitis; Facial Pain; Matrix Metalloproteinases; Tissue Inhibitor of Metalloproteinases; Immunoenzyme Techniques; Analysis of Variance; Linear Models; Sensitivity and Specificity; Statistics, Nonparametric; Case-Control Studies; Adolescent; Adult; Aged; Middle Aged; Female; Male; Matrix Metalloproteinase 3; Matrix Metalloproteinase 1en
dc.titleMatrix metalloproteinase and tissue inhibitor of metalloproteinase in serum and lavage synovial fluid of patients with temporomandibular joint disordersen
dc.typeJournal articleen
dc.identifier.rmid0001000510en
dc.identifier.doi10.1054/bjom.2000.0306en
dc.identifier.pubid63713-
pubs.library.collectionDentistry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidGoss, A. [0000-0002-2658-3836]en
Appears in Collections:Dentistry publications

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