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https://hdl.handle.net/2440/17397
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Type: | Journal article |
Title: | Paradoxical effect of n-3-containing vegetable oils on long-chain n-3 fatty acids in rat heart |
Author: | Cleland, L. Gibson, R. Pedler, J. James, M. |
Citation: | Lipids, 2005; 40(10):995-998 |
Publisher: | Amer Oil Chemists Soc A O C S Press |
Issue Date: | 2005 |
ISSN: | 0024-4201 1558-9307 |
Statement of Responsibility: | Leslie G. Cleland, Robert A. Gibson, Janet Pedler, and Michael J. James |
Abstract: | Flaxseed, echium, and canola oils contain α-linolenic acid (18:3n-3, ALA) in a range of concentrations. To examine their effect on elevating cardiac levels of long-chain n-3 FA, diets based on these n-3-containing vegetable oils were fed to rats for 4 wk. Sunflower oil, which contains little ALA, was a comparator. Despite canola oil having the lowest ALA content of the three n-3-containing vegetable oils, it was the most potent for elevating DHA (22:6n-3) levels in rat hearts and plasma. However, the relative potencies of the dietary oils for elevation of EPA (20:5n-3) in heart and plasma followed the same rank order as their ALA content, i.e., flaxseed > echium > canola > sunflower oil. This paradox may be explained by lower ALA intake leading to decreased competition for Δ6 desaturase activity between ALA and the 24:5n-3 FA precursor to DHA formation. |
Keywords: | Myocardium Heart Animals Rats Dietary Fats, Unsaturated Fatty Acids, Omega-3 alpha-Linolenic Acid Docosahexaenoic Acids Eicosapentaenoic Acid Fatty Acids Fatty Acids, Unsaturated Arachidonic Acid Fatty Acids, Omega-6 Phospholipids Plant Oils Female |
Description: | The original publication can be found at www.springerlink.com |
DOI: | 10.1007/s11745-005-1461-6 |
Published version: | http://www.springerlink.com/content/g10q657453442411/fulltext.pdf |
Appears in Collections: | Aurora harvest 2 Paediatrics publications |
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