Adelaide Research & Scholarship
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https://hdl.handle.net/2440/19636
| Type: | Thesis |
| Title: | Amphibian antimicrobial peptides : their structures and mechanisms of action / by Brian Cheng San Chia. |
| Author: | Chia, Brian Cheng San |
| Issue Date: | 2000 |
| School/Discipline: | Dept. of Chemistry |
| Abstract: | Three antimicrobial peptides, maculatin 1.1, uperin 3.6 and caerin 4.1 have been isolated from the respective skin glands of the Australian amphibians Litoria genimaculata, Uperoleia mjobergii and Litoria caerulea. To gain a deeper insight into their mechanisms of action, three dimensional structural studies have been conducted using circular dichroism, two-dimensional nuclear resonance and computer modelling techniques. The role of central flexibility within antibiotic peptides in their interaction with bacterial membranes is also discussed. |
| Dissertation Note: | Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 2000 |
| Subject: | Anti-infective agents Protein drugs Peptides Therapeutic use Microbial peptides |
| Description: | Copy of author's previously published works inserted. Bibliography: leaves 183-220. xiii, 226 leaves : ill. (chiefly col.) ; 30 cm. |
| Provenance: | This electronic version is made publicly available by the University of Adelaide in accordance with its open access policy for student theses. Copyright in this thesis remains with the author. This thesis may incorporate third party material which has been used by the author pursuant to Fair Dealing exception. If you are the author of this thesis and do not wish it to be made publicly available or If you are the owner of any included third party copyright material you wish to be removed from this electronic version, please complete the take down form located at: http://www.adelaide.edu.au/legals |
| Appears in Collections: | Research Theses |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01front.pdf | 414.29 kB | Adobe PDF | View/Open | |
| 02whole.pdf | 10.51 MB | Adobe PDF | View/Open | |
| Permissions Restricted Access | Library staff access only | 523.77 kB | Adobe PDF | View/Open |
| Restricted Restricted Access | LIbrary staff access only | 24.96 MB | Adobe PDF | View/Open |
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