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Type: Journal article
Title: Switching between methadone and morphine for maintenance treatment of opioid dependence: Impact on pain sensitivity and mood status
Author: Mitchell, T.
White, J.
Somogyi, A.
Bochner, F.
Citation: American Journal on Addictions, 2006; 15(4):311-315
Publisher: Taylor & Francis Inc
Issue Date: 2006
ISSN: 1055-0496
Statement of
Timothy B. Mitchell, Jason M. White, Andrew A. Somogyi and Felix Bochner
Abstract: Methadone maintenance is associated with hyperalgesia and elevated mood disturbance - effects opposite to those induced by acute opioid administration, which may undermine outcomes during substitution therapy. This study examined the impact of switching between methadone and slow-release morphine on pain sensitivity and mood status in 14 methadone maintenance patients using an open-label crossover design. Pain responses were nearly identical for each drug. Patients reporting inadequate withdrawal suppression on methadone showed greater mood stability when transferred to morphine, but overall mood disturbance levels did not differ between drugs. Hyperalgesia and mood disturbance cannot be resolved by changing from methadone to morphine maintenance.
Keywords: Affective disorders; drug abuse; drug addicts; hyperalgesia; morphine abuse; opioid abuse; pain; psychotropic drugs; methodone abuse
RMID: 0020061007
DOI: 10.1080/10550490600754374
Appears in Collections:Pharmacology publications

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