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https://hdl.handle.net/2440/23013
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Type: | Journal article |
Title: | Anti-inflammatory agents in the management of alimentary mucositis |
Author: | Lalla, R. Schubert, M. Bensadoun, R. Keefe, D. |
Citation: | Supportive Care in Cancer, 2006; 14(6):558-565 |
Publisher: | Springer-Verlag |
Issue Date: | 2006 |
ISSN: | 0941-4355 1433-7339 |
Statement of Responsibility: | Rajesh V. Lalla, Mark M. Schubert, Rene-Jean Bensadoun and Dorothy Keefe |
Abstract: | <h4>Background</h4>Alimentary mucositis is a significant complication of cancer therapy, with important clinical and economic implications.<h4>Materials and methods</h4>In June 2005, the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology conducted an evidence-based review of the literature on alimentary mucositis. The goal of this literature review was to update previously published guidelines for the management of mucositis.<h4>Results</h4>This article reports the findings of the subgroup charged with reviewing the literature related to anti-inflammatory interventions. Considerable preclinical and clinical evidence suggests that the use of anti-inflammatory agents may be a promising approach to reduce the severity of mucositis. However, there was not enough evidence to support any new guidelines advocating the use of any specific anti-inflammatory intervention.<h4>Conclusion</h4>Thus, there is a need for well-designed clinical trials evaluating the use of anti-inflammatory agents in the management of mucositis. |
Keywords: | Animals Humans Neoplasms Gastrointestinal Diseases Stomatitis Flurbiprofen Benzydamine Triazines Allopurinol Misoprostol Metalloproteins Anti-Inflammatory Agents Anti-Ulcer Agents Antineoplastic Agents Radiation-Protective Agents Radiotherapy Severity of Illness Index Drug Evaluation Evidence-Based Medicine Research Design Health Services Needs and Demand Mucositis Clinical Trials as Topic Practice Guidelines as Topic |
Description: | Background Alimentary mucositis is a significant complication of cancer therapy, with important clinical and economic implications. Materials and methods In June 2005, the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology conducted an evidence-based review of the literature on alimentary mucositis. The goal of this literature review was to update previously published guidelines for the management of mucositis. Results This article reports the findings of the subgroup charged with reviewing the literature related to anti-inflammatory interventions. Considerable preclinical and clinical evidence suggests that the use of anti-inflammatory agents may be a promising approach to reduce the severity of mucositis. However, there was not enough evidence to support any new guidelines advocating the use of any specific anti-inflammatory intervention. Conclusion Thus, there is a need for well-designed clinical trials evaluating the use of anti-inflammatory agents in the management of mucositis. The original publication can be found at www.springerlink.com |
DOI: | 10.1007/s00520-006-0050-9 |
Published version: | http://www.springerlink.com/content/e76721h283553026/ |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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