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|Title:||Expression of the immediate early gene, c-fos, in fetal brain after whole of gestation exposure of pregnant mice to global system for mobile communication microwaves|
|Citation:||Pathology, 2006; 38(4):333-335|
|Publisher:||Taylor & Francis|
|Abstract:||AIMS: To study immediate early gene, c-fos, expression as a marker of neural stress after whole of gestation exposure of the fetal mouse brain to mobile telephone-type radiofrequency fields. METHODS: Using a purpose-designed exposure system at 900 MHz, pregnant mice were given a single, far-field, whole body exposure at a specific absorption rate of 4 W/kg for 60 min/day from day 1 to day 19 of gestation. Pregnant control mice were sham-exposed or freely mobile in a cage without further restraint. Immediately prior to parturition on gestational day 19, fetal heads were collected, fixed in 4% paraformaldehyde and paraffin embedded. Any stress response in the brain was detected by c-fos immunohistochemistry in the cerebral cortex, basal ganglia, thalamus, hippocampus, midbrain, cerebellum and medulla. RESULTS: c-fos expression was of limited, but consistent, neuroanatomical distribution and there was no difference in immunoreactivity between exposed and control brains. CONCLUSION: In this animal model, no stress response was detected in the fetal brain using c-fos immunohistochemistry after whole of gestation exposure to mobile telephony.|
|Keywords:||Brain; Animals; Mice, Inbred BALB C; Mice; Proto-Oncogene Proteins c-fos; Immunohistochemistry; Gene Expression Regulation, Developmental; Pregnancy; Genes, fos; Microwaves; Cellular Phone; Female; Stress, Physiological|
|Appears in Collections:||Pathology publications|
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