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Type: Journal article
Title: Neonatal adrenal function after repeat dose prenatal corticosteroids: A randomized controlled trial
Author: Ashwood, P.
Crowther, C.
Willson, K.
Haslam, R.
Kennaway, D.
Hiller, J.
Robinson, J.
Citation: American Journal of Obstetrics and Gynecology, 2006; 194(3):861-867
Publisher: Mosby Inc
Issue Date: 2006
ISSN: 0002-9378
Statement of
Patricia J. Ashwood; Caroline A. Crowther; Kristyn J. Willson; Ross R. Haslam; David J. Kennaway; Janet E. Hiller; and Jeffrey S. Robinson
Abstract: OBJECTIVE: Do repeat prenatal corticosteroids suppress neonatal cortisol concentrations? STUDY DESIGN: Randomized controlled trial of women given weekly repeat corticosteroids or saline placebo, while at risk of preterm birth, until 32 weeks' gestation. RESULTS: Cord serum cortisol concentrations in infants exposed to repeat corticosteroids were similar compared with infants exposed to a single course of corticosteroids (mean difference -26 nmol/L (95% CI -57, 5 nmol/L, P = .10), as were prestress salivary cortisol concentrations on day 3 (median 16.5 vs 15.3 nmol/L, P = .96). The adrenal response to a stressor on day 3 was lower in the repeat corticosteroid group compared with the single course group (median 11.9 vs 21.4 nmol/L, P = .02). Cortisol concentrations were lower in the repeat corticosteroid group on day 7 (median 11.7 vs 18.2 nmol/L, P = .04), but not on days 14 and 21. CONCLUSION: The short- or long-term clinical impact, if any, of these changes in adrenal function needs to be determined.
Keywords: Repeat corticosteroids; Neonatal adrenal suppression; Randomized trial
Description: Copyright © 2006 Mosby, Inc. All rights reserved.
RMID: 0020060209
DOI: 10.1016/j.ajog.2005.08.063
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Appears in Collections:Obstetrics and Gynaecology publications

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