Adelaide Research & Scholarship
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https://hdl.handle.net/2440/23483
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| Type: | Journal article |
| Title: | Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage |
| Author: | Bowen, J. Gibson, R. Cummins, A. Keefe, D. |
| Citation: | Supportive Care in Cancer, 2006; 14(7):713-731 |
| Publisher: | Springer-Verlag |
| Issue Date: | 2006 |
| ISSN: | 0941-4355 1433-7339 |
| Statement of Responsibility: | Joanne M. Bowen, Rachel J. Gibson, Adrian G. Cummins and Dorothy M. K. Keefe |
| Abstract: | Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist. |
| Keywords: | mucositis p53 Bcl-2 family caspases |
| Description: | The original publication can be found at www.springerlink.com |
| DOI: | 10.1007/s00520-005-0004-7 |
| Published version: | http://www.springerlink.com/content/fu72634746884328/ |
| Appears in Collections: | Aurora harvest 6 Medicine publications |
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