Adelaide Research & Scholarship
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https://hdl.handle.net/2440/2470
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| Type: | Journal article |
| Title: | Label-free bioaffinity detection using terahertz technology |
| Author: | Mickan, S. Menikh, A. Liu, H. Mannella, C. MacColl, R. Abbott, D. Munch, J. Zhang, X. |
| Citation: | Physics in Medicine and Biology, 2002; 47(21):3789-3795 |
| Publisher: | IOP Publishing Ltd |
| Issue Date: | 2002 |
| ISSN: | 0031-9155 1361-6560 |
| Statement of Responsibility: | Samuel P Mickan, Abdellah Menikh, Haibo Liu, Carmen A Mannella, Robert MacColl, Derek Abbott, Jesper Munch and X-C Zhang |
| Abstract: | We report the first use of differential terahertz time-domain spectroscopy for bioaffinity sensing. Binding is observed by measuring the transmission of a thin layer of biotin bound to the sensor protein avidin. We demonstrate the THz wave transmission of a sub-micron-thick film and sensitivity to 0.1 µg cm−2 of biotin. These results point the way for a host of biosensor applications using T-rays, or pulsed far-infrared (FIR) radiation. |
| Keywords: | Macromolecular Substances Avidin Affinity Labels Membranes, Artificial Sensitivity and Specificity Refractometry Spectrum Analysis Biosensing Techniques Protein Binding Biotin Electromagnetic Phenomena Surface Properties Microwaves Equipment Design |
| Description: | © 2002 IOP Publishing |
| DOI: | 10.1088/0031-9155/47/21/317 |
| Published version: | http://www.iop.org/EJ/abstract/0031-9155/47/21/317/ |
| Appears in Collections: | Aurora harvest 2 Electrical and Electronic Engineering publications Environment Institute publications Physics publications |
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