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|Title:||Failure to confirm association of a polymorphism in ABCB1 with multidrug-resistant epilepsy|
|Citation:||Neurology, 2004; 63(6):1090-1092|
|Publisher:||Lippincott Williams & Wilkins|
|Abstract:||Alteration of ATP-binding cassette subfamily B member 1 transporter (ABCB1) can plausibly cause drug-resistant epilepsy as it influences brain penetration of drugs. The CC genotype at the ABCB1 C3435T polymorphism was reported to be associated with multidrug resistance. A replication study in 401 drug-resistant and 208 drug-responsive subjects with epilepsy showed no significant association between the CC genotype and drug-resistant epilepsy. The authors suggest the initial association may have arisen by chance.|
|Keywords:||Hippocampus; Epilepsy, Temporal Lobe; Sclerosis; Anticonvulsants; Reproducibility of Results; Amino Acid Substitution; Drug Resistance, Multiple; Gene Frequency; Genotype; Haplotypes; Mutation, Missense; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Alleles; Exons; Victoria; ATP Binding Cassette Transporter, Subfamily B, Member 1|
|Description:||Copyright © 2004 American Academy of Neurology|
|Appears in Collections:||Molecular and Biomedical Science publications|
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