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Type: Journal article
Title: The effect of depression in an animal model on 5'-Ectonucleotidase, antibody production, and tissue ascorbate stores
Author: Blake-Mortimer, J.
Winefield, A.
Chalmers, A.
Citation: Journal of General Psychology: experimental, physiological, and comparative psychology, 1998; 125(2):129-146
Publisher: Taylor & Francis (Routledge)
Issue Date: 1998
ISSN: 0022-1309
Statement of
J. S. Blake-Mortimer , A. H. Winefield & A. H. Chalmers
Abstract: The learned helplessness model of depression in rats was tested. It was hypothesized that 5′-ectonucleotidase (NT), ascorbate, and antibody to sheeps' red blood cells (SRBC) are significantly reduced in rats who experienced uncontrollable shock, compared with rats who did not receive shock or could control it. During a learned-helplessness manipulation, antibody response to SRBC and NT values were unaffected. However, tissue ascorbate stores fell significantly, by 20–30%. The lack of effects on antibody responses and NT are discussed in terms of the acute nature of the stressor used in this model, as opposed to the more chronic stressors that have occurred in the human model.
Keywords: Animals; Rats; Rats, Sprague-Dawley; Disease Models, Animal; Ascorbic Acid; 5'-Nucleotidase; Antioxidants; Analysis of Variance; Electroshock; Escape Reaction; Depression; Stress, Psychological; Helplessness, Learned; Antibody Formation; Time Factors
RMID: 0030006499
DOI: 10.1080/00221309809595538
Appears in Collections:Psychology publications

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