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https://hdl.handle.net/2440/34698
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dc.contributor.author | Fang, J. | - |
dc.contributor.author | Kinlay, S. | - |
dc.contributor.author | Beltrame, J. | - |
dc.contributor.author | Hikiti, H. | - |
dc.contributor.author | Wainstein, M. | - |
dc.contributor.author | Behrendt, D. | - |
dc.contributor.author | Suh, J. | - |
dc.contributor.author | Frei, B. | - |
dc.contributor.author | Mudge, G. | - |
dc.contributor.author | Selwyn, A. | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | The Lancet, 2002; 359(9312):1108-1113 | - |
dc.identifier.issn | 0140-6736 | - |
dc.identifier.issn | 1474-547X | - |
dc.identifier.uri | http://hdl.handle.net/2440/34698 | - |
dc.description.abstract | Background: Cardiac transplantation is associated with oxidant stress, which may contribute to the development of accelerated coronary arteriosclerosis. We postulated that treatment with antioxidant vitamins C and E would retard the progression of transplant-associated arteriosclerosis. Methods: In a double-blind prospective study, 40 patients (0–2 years after cardiac transplantation) were randomly assigned vitamin C 500 mg plus vitamin E 400 IU, each twice daily (n=19), or placebo (n=21) for 1 year. The primary endpoint was the change in average intimal index (plaque area divided by vessel area) measured by intravascular ultrasonography (IVUS). Coronary endothelium-dependent vasoreactivity was assessed with intracoronary acetylcholine infusions. IVUS, coronary vasoreactivity, and vitamin C and E plasma concentrations were assessed at baseline and at 1 year follow-up. All patients received pravastatin. Analyses were by intention to treat. Findings: Vitamin C and E concentrations increased in the vitamin group (vitamin C 43 [SD 21] to 103 [43] μmol/L; vitamin E 24 [14] to 65 [27] μmol/L) but did not change in the placebo group (vitamin C 45 [15] vs 43 [16] μmol/L; vitamin E 27 [14] vs 27 [9] μmol/L; p<0•0001 for difference between groups). During 1 year of treatment, the intimal index increased in the placebo group by 8% (SE 2) but did not change significantly in the treatment group (0•8% [1]; p=0•008). Coronary endothelial function remained stable in both groups. Interpretation Supplementation with antioxidant vitamins C and E retards the early progression of transplant-associated coronary arteriosclerosis. | - |
dc.description.statementofresponsibility | James C Fang, Scott Kinlay, John Beltrame, Hiroyuki Hikiti, Marco Wainstein, Dominik Behrendt, Jung Suh, Balz Frei, Gilbert H Mudge, Andrew P Selwyn, Peter Ganz | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/31066/description#description | - |
dc.language.iso | en | - |
dc.publisher | Lancet Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/s0140-6736(02)08154-0 | - |
dc.subject | Coronary Vessels | - |
dc.subject | Endothelium, Vascular | - |
dc.subject | Tunica Intima | - |
dc.subject | Humans | - |
dc.subject | Disease Progression | - |
dc.subject | Ascorbic Acid | - |
dc.subject | Vitamin E | - |
dc.subject | Antioxidants | - |
dc.subject | Ultrasonography, Interventional | - |
dc.subject | Drug Therapy, Combination | - |
dc.subject | Heart Transplantation | - |
dc.subject | Prospective Studies | - |
dc.subject | Double-Blind Method | - |
dc.subject | Vasodilation | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Coronary Artery Disease | - |
dc.title | Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial. | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0140-6736(02)08154-0 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Beltrame, J. [0000-0002-4294-6510] | - |
Appears in Collections: | Aurora harvest Medicine publications |
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