Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/34709
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Perspectives on cancer therapy-induced mucosal injury : Pathogenesis, measurement, epidemiology, and consequences for patients
Author: Sonis, S.
Elting, L.
Keefe, D.
Peterson, D.
Schubert, M.
Hauer-Jensen, M.
Bekele, B.
Raber-Durlacher, J.
Rubenstein, E.
Donelly, J.
Citation: Cancer, 2004; 100(s9):1995-2025
Publisher: John Wiley & Sons Inc
Issue Date: 2004
ISSN: 0008-543X
1097-0142
Statement of
Responsibility: 
Stephen T. Sonis, Linda S. Elting, Dorothy Keefe, Douglas E. Peterson, Mark Schubert, Martin Hauer-Jensen, B. Nebiyou Bekele, Judith Raber-Durlacher, J. Peter Donnelly, Edward B. Rubenstein, for the Mucositis Study Section of the Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology
Abstract: BACKGROUND: A frequent complication of anticancer treatment, oral and gastrointestinal (GI) mucositis, threatens the effectiveness of therapy because it leads to dose reductions, increases healthcare costs, and impairs patients' quality of life. The Multinational Association of Supportive Care in Cancer and the International Society for Oral Oncology assembled an international multidisciplinary panel of experts to create clinical practice guidelines for the prevention, evaluation, and treatment of mucositis. METHODS: The panelists examined medical literature published from January 1966 through May 2002, presented their findings at two separate conferences, and then created a writing committee that produced two articles: the current study and another that codifies the clinical implications of the panel's findings in practice guidelines. RESULTS: New evidence supports the view that oral mucositis is a complex process involving all the tissues and cellular elements of the mucosa. Other findings suggest that some aspects of mucositis risk may be determined genetically. GI proapoptotic and antiapoptotic gene levels change along the GI tract, perhaps explaining differences in the frequency with which mucositis occurs at different sites. Studies of mucositis incidence in clinical trials by quality and using meta-analysis techniques produced estimates of incidence that are presented herein for what to our knowledge may be a broader range of cancers than ever presented before. CONCLUSIONS: Understanding the pathobiology of mucositis, its incidence, and scoring are essential for progress in research and care directed at this common side-effect of anticancer therapies.
Keywords: stomatitis; oral mucositis; gastrointestinal mucositis; mucosal barrier injury; mucositis clinical assessment scales; mucositis etiopathogenesis
Description: Copyright © 2004 American Cancer Society
RMID: 0020064357
DOI: 10.1002/cncr.20162
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.