Adelaide Research & Scholarship
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https://hdl.handle.net/2440/34886
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| Type: | Journal article |
| Title: | The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K⁺ channels of the alga Nitella hookeri |
| Other Titles: | The synthesis of NPPB and NPBB by reductive amination and the effects of these compounds on K(+) channels of the alga Nitella hookeri |
| Author: | Giles, K. Humphries, M. Abell, A. Garrill, A. |
| Citation: | Bioorganic and Medicinal Chemistry Letters, 2003; 13(2):293-295 |
| Publisher: | Pergamon-Elsevier Science Ltd |
| Issue Date: | 2003 |
| ISSN: | 0960-894X 1464-3405 |
| Statement of Responsibility: | Kristian R. Giles, Mark Humphries, Andrew Abell and Ashley Garrill |
| Abstract: | This paper communicates a new synthesis of the ion channel inhibitors NPPB and NPBB using a simple reductive amination sequence. The synthesised compounds were found to reduce channel amplitude of a K⁺ channel present in cytoplasmic droplets of Nitella hookeri. |
| Keywords: | Cytoplasm Nitrobenzoates Potassium Channels Potassium Channel Blockers Indicators and Reagents Kinetics Chlorophyta Aminobenzoates |
| Rights: | © 2002 Elsevier Science Ltd. All rights reserved. |
| DOI: | 10.1016/S0960-894X(02)00920-4 |
| Published version: | http://dx.doi.org/10.1016/s0960-894x(02)00920-4 |
| Appears in Collections: | Aurora harvest 6 Chemistry publications |
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