Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/36372
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Type: | Journal article |
Title: | An amino acid N-derivatising group that can be coloured on demand |
Author: | Abell, A. Martyn, D. May, B. Nabbs, B. |
Citation: | Tetrahedron Letters: the international journal for the rapid publication of all preliminary communications in organic chemistry, 2002; 43(20):3673-3675 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2002 |
ISSN: | 0040-4039 |
Statement of Responsibility: | Andrew D. Abell, Derek C. Martyn, Barnaby C. H. May and Brent K. Nabbs |
Abstract: | A method is presented whereby an amino acid is reacted with 5-formyl-1H-pyrrole-2-carboxylic acid to give an N-derivatised tag that has a latent ability to be coloured. A characteristic red pyrrolizin-3-one (coloured tag) is then revealed on treatment with hydrocinnamoyl chloride. This sequence has been carried out on amino acids in solution, and on solid phase, and also on dipeptides. A method is presented whereby an amino acid is reacted with 5-formyl-1H-pyrrole-2-carboxylic acid to give an N-derivatised tag that has a latent ability to be coloured. |
DOI: | 10.1016/S0040-4039(02)00625-1 |
Description (link): | http://www.sciencedirect.com/science/journal/00404039 |
Published version: | http://dx.doi.org/10.1016/s0040-4039(02)00625-1 |
Appears in Collections: | Aurora harvest 6 Chemistry publications |
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