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https://hdl.handle.net/2440/37059
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Type: | Journal article |
Title: | Long-term results of low-dose intravenous ciclosporin for acute severe ulcerative colitis |
Author: | Rayner, C. McCormack, G. Emmanuel, A. Kamm, M. |
Citation: | Alimentary Pharmacology and Therapeutics, 2003; 18(3):303-308 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2003 |
ISSN: | 0269-2813 1531-0132 |
Statement of Responsibility: | C. K. Rayner, G. McCormack, A. V. Emmanuel & M. A. Kamm |
Abstract: | Background: Intravenous ciclosporin for acute, severe colitis is usually administered in a dose of 4 mg/kg/day, with concurrent intravenous steroids. This is associated with considerable morbidity. We have been using a low-dose regimen, most commonly without concurrent steroids, for seven years, and present the outcome. Methods: Records of all patients admitted for severe ulcerative colitis, treated by one physician over seven years, were reviewed. Results: Thirty-one patients received low-dose intravenous ciclosporin (2 mg/kg/day) for a median 8 days. Eleven early patients received concurrent intravenous corticosteroids. Three patients had hypertension requiring dose reduction, one elevated creatinine and one elevated liver enzymes (all transient), and four experienced infection (two arm cellulitis, one perianal abscess, one post-operative wound infection). Twenty-four patients (77%) avoided urgent colectomy, and were discharged on oral ciclosporin and azathioprine. After a median 18 months (range 3–77), 14 patients (45% of total) avoided colectomy, of whom eight had flares responding to medical therapy and two had persistent, mildly active disease. Conclusions: Low-dose intravenous ciclosporin (2 mg/kg/day), usually used as a monotherapy and followed by azathioprine, achieves similar long-term efficacy to higher dose ciclosporin combined with steroids in severe acute ulcerative colitis. Morbidity appears to be low. |
Keywords: | Humans Colitis, Ulcerative Acute Disease Cyclosporine Treatment Outcome Retreatment Colectomy Infusions, Intravenous Adolescent Adult Middle Aged Female Male |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1046/j.1365-2036.2003.01618.x |
Published version: | http://dx.doi.org/10.1046/j.1365-2036.2003.01618.x |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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