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https://hdl.handle.net/2440/37126
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Type: | Journal article |
Title: | A placebo-controlled pharmacodynamic and pharmacokinetic interaction study between tamsulosin and acenocoumarol |
Author: | Rolan, P. Terpstra, I. Clarke, C. Mullins, F. Visser, J. |
Citation: | British Journal of Clinical Pharmacology, 2003; 55(3):314-316 |
Publisher: | Blackwell Publishing Ltd |
Issue Date: | 2003 |
ISSN: | 0306-5251 1365-2125 |
Statement of Responsibility: | P. Rolan, I. J. Terpstra, C. Clarke, F. Mullins and J. N. Visser |
Abstract: | AIM: To evaluate pharmacokinetic and pharmacodynamic interactions between tamsulosin and acenocoumarol. METHODS: Twelve healthy volunteers received tamsulosin 0.4 mg or placebo once daily for 9 days in a double-blind, cross-over study. On day 5 of each study period, a single 10-mg oral dose of racemic acenocoumarol was administered. RESULTS: The ratios (point estimates (90% confidence intervals)) of values in the presence and absence of tamsulosin were: AUCPT 1.01 (0.98, 1.03); maximum prothrombin time (Ptmax) 0.99 (0.94, 1.05); AUC (R)-acenocoumarol 1.02 (0.90, 1.16), and AUC (S)-acenocoumarol 1.03 (0.89, 1.20). Both combinations, tamsulosin and placebo with acenocoumarol, were well-tolerated. CONCLUSIONS: Multiple doses of tamsulosin had no effect on the pharmacokinetics or pharmacodynamics of a single high dose of acenocoumarol. |
Keywords: | Acenocoumarol drug interaction oral anticoagulants tamsulosin |
DOI: | 10.1046/j.1365-2125.2003.01793.x |
Published version: | http://dx.doi.org/10.1046/j.1365-2125.2003.01793.x |
Appears in Collections: | Aurora harvest Pharmacology publications |
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