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Type: Journal article
Title: Pathological evidence of encephalomyelitis in the stiff man syndrome with anti-GAD antibodies
Author: Warren, J.
Scott, G.
Blumbergs, P.
Thompson, P.
Citation: Journal of Clinical Neuroscience, 2002; 9(3):328-329
Publisher: Churchill Livingstone
Issue Date: 2002
ISSN: 0967-5868
Statement of
Jason D. Warren, Grace Scott, Peter C. Blumbergs, and Philip D. Thompson
Abstract: We report the case of a 57 year old woman with typical clinical features of the stiff man syndrome (SMS) and antibodies to glutamic acid decarboxylase (antiGADAb), who developed a supranuclear gaze palsy, ileus and died of bronchopneumonia eight years after the onset of illness. Post mortem examination revealed perivascular lymphocyte cuffing throughout the cerebral hemispheres, brainstem and spinal cord and neuronal loss in medial anterior horns of the cervical spinal cord. These findings support the notion that the SMS and progressive encephalomyelitis with rigidity (PER) form a clinical and pathologic continuum.
Keywords: Central Nervous System; Humans; Stiff-Person Syndrome; Encephalomyelitis; Glutamate Decarboxylase; Antibodies; Fatal Outcome; Middle Aged; Female
Description: Copyright © 2002 Elsevier Science Ltd. All rights reserved.
RMID: 0020071724
DOI: 10.1054/jocn.2001.1014
Appears in Collections:Medicine publications

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