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https://hdl.handle.net/2440/3933
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dc.contributor.author | Ong, J. | - |
dc.contributor.author | Marino, V. | - |
dc.contributor.author | Parker, D. | - |
dc.contributor.author | Kerr, D. | - |
dc.contributor.author | Blythin, D. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | European Journal of Pharmacology, 1999; 369(1):33-37 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.issn | 1879-0712 | - |
dc.identifier.uri | http://hdl.handle.net/2440/3933 | - |
dc.description.abstract | In rat neocortical slices maintained in Mg2+-free Krebs medium, baclofen depressed the rate of spontaneous discharges in a concentration-dependent manner (EC50 = 4.5 microM). This depression was reversibly antagonised by 5-(S,R)-hydroxymethyl-5-methylmorpholinyl-2-(R,S)-acetic acid (Sch 54679) and 2-(R,S)-5-[spirocyclopentyl]-morpholinyl-acetic acid (Sch 51324) (respective pA2 values of 5.8+/-0.15 and 5.4+/-0.2). In electrically-stimulated slices preloaded with [3H]gamma-aminobutyric acid (GABA), Sch 54679 (EC50 = 3 microM) was 2.3 times more potent than Sch 51324 (EC50 = 7 microM) in increasing [3H]GABA release through antagonism of GABA(B) autoreceptors. These structurally novel analogues may be pharmacologically useful for elucidating GABA(B) receptor functions. | - |
dc.description.statementofresponsibility | Jennifer Ong, Victor Marino, David A.S Parker, David I.B Kerr, David J Blythin | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.rights | Copyright © 1999 Elsevier Science B.V. All rights reserved. | - |
dc.source.uri | http://dx.doi.org/10.1016/s0014-2999(99)00047-3 | - |
dc.subject | Baclofen | - |
dc.subject | GABAB receptor | - |
dc.subject | GABAB receptor antagonist | - |
dc.subject | Sch 54679 | - |
dc.subject | Sch 51324 | - |
dc.subject | Neocortical slice, rat | - |
dc.title | Antagonism of GABAB receptors by morpholino-2-acetic acid derivatives Sch 54679 and Sch 51324 in rat brain | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/S0014-2999(99)00047-3 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Ong, J. [0000-0002-0958-460X] | - |
Appears in Collections: | Aurora harvest 2 Dentistry publications |
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