Please use this identifier to cite or link to this item:
Scopus Web of Science® Altmetric
Type: Journal article
Title: Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons
Author: Chattopadhyay, A.
Gray, L.
Patton, L.
Caplan, D.
Slade, G.
Tien, H.
Shugars, D.
Citation: Infection and Immunity, 2004; 72(4):1956-1963
Publisher: Amer Soc Microbiology
Issue Date: 2004
ISSN: 0019-9567
Statement of
Amit Chattopadhyay, Laurie R. Gray, Lauren L. Patton, Daniel J. Caplan, Gary D. Slade, Hsaio-Chuan Tien, and Diane C. Shugars
Abstract: Oropharyngeal candidiasis, typically caused by Candida albicans, is the most common oral disease associated with human immunodeficiency virus type 1 (HIV-1) infection. Secretory leukocyte protease inhibitor (SLPI), a 12-kDa antiprotease, suppresses the growth of C. albicans in vitro. To determine whether the mucosal protein plays a role in protecting oral tissues against fungal infection, we conducted a cross-sectional study investigating the oral and systemic health and salivary SLPI levels in 91 dentate HIV-1-infected adults receiving medical care in the southeastern United States. Participants with a self-reported history of clinical oropharyngeal candidiasis during the previous 2 years constituted the test group (n = 52), while the comparison group (n = 39) had no oropharyngeal candidiasis during that period. Data collected from medical records, oral examination, and SLPI enzyme-linked immunosorbent assay quantitation of whole saliva were analyzed by t test, analysis of variance, linear regression, and unconditional logistic regression. The test group had a significantly higher mean salivary SLPI level than the comparison group (1.9 microg/ml versus 1.1 microg/ml, P < 0.05). Linear regression modeling identified CD4 cell count and history of oropharyngeal candidiasis as key predictors of salivary SLPI and revealed a significant interaction (P < 0.05) between immunosuppression (CD4 cell count below 200 cells/ microl) and positive history of oropharyngeal candidiasis in predicting salivary SLPI level. By logistic regression modeling, a salivary SLPI level exceeding 2.1 microg/ml, low CD4 count, antiretroviral monotherapy, and smoking were key predictors of oropharyngeal candidiasis. These data support a key role for SLPI in the oral mucosal defense against C. albicans. The antimicrobial mucosal protein may serve as an indicator of previous oropharyngeal candidiasis infection among immunosuppressed persons.
Keywords: Saliva
Candida albicans
AIDS-Related Opportunistic Infections
Candidiasis, Oral
HIV Infections
CD4 Lymphocyte Count
Cross-Sectional Studies
Proteinase Inhibitory Proteins, Secretory
Secretory Leukocyte Peptidase Inhibitor
Rights: © 2004, American Society for Microbiology. All Rights Reserved.
DOI: 10.1128/IAI.72.4.1956-1963.2004
Published version:
Appears in Collections:Aurora harvest 6
Dentistry publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.