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|Title:||Tranexamic acid mouthwash - A prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions|
|Citation:||International Journal of Oral and Maxillofacial Surgery, 2003; 32(5):504-507|
|G. Carter and A. Goss|
|Abstract:||This prospective randomized study analyses the use of a prescribed 4.8% tranexamic acid post-operative mouthwash over 2 days vs 5 days to prevent bleeding in patients taking warfarin who require dental extractions. Eighty-five patients therapeutically anticoagulated with warfarin for various conditions, ranging in age from 21 to 86 years and requiring dental extractions, were randomly divided into two groups. Group A postoperatively received a 4.8% tranexamic acid mouthwash to be used over a 2-day period. Group B received the same mouthwash and instructions postoperatively, to be taken over 5 days. All procedures were performed on an ambulatory basis under local anaesthetic by the same surgeon. Patients were reviewed 1, 3, and 7 days postoperatively to assess bleeding. Eighty-two of the 85 patients encountered no postoperative problems. Two patients in group A and one in group B had minor postoperative bleeds that required minor ambulatory intervention to control. This study shows that a 2-day postoperative course of a 4.8% tranexamic acid mouthwash is as equally effective as a 5-day course in controlling haemostasis post-dental extractions in patient's anticoagulated with warfarin.|
|Keywords:||Humans; Oral Hemorrhage; Postoperative Hemorrhage; Tranexamic Acid; Warfarin; Anticoagulants; Antifibrinolytic Agents; Mouthwashes; Polypharmacy; Tooth Extraction; Administration, Topical; Prospective Studies; Single-Blind Method; Dental Care for Chronically Ill; Time Factors; Adult; Aged; Middle Aged; Female; Male|
|Description:||Copyright © 2003 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Science Ltd.|
|Appears in Collections:||Dentistry publications|
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