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https://hdl.handle.net/2440/41969
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Type: | Journal article |
Title: | Effects of protein on glycemic and incretin responses and gastric emptying after oral glucose in healthy subjects |
Author: | Karamanlis, A. Chaikomin, R. Doran, S. Bellon, M. Bartholomeusz, D. Wishart, J. Jones, K. Horowitz, M. Rayner, C. |
Citation: | American Journal of Clinical Nutrition, 2007; 86(5):1364-1368 |
Publisher: | Amer Soc Clinical Nutrition |
Issue Date: | 2007 |
ISSN: | 0002-9165 1938-3207 |
Abstract: | <h4>Background</h4>Dietary interventions represent a promising therapeutic strategy to optimize postprandial glycemia. The addition of protein to oral glucose has been reported to improve the glycemic profile.<h4>Objective</h4>The aim of the current study was to evaluate the mechanisms by which protein supplementation lowers the blood glucose response to oral glucose.<h4>Design</h4>Nine healthy men were studied on 3 d each in a random order. Subjects consumed 300-mL drinks containing either 50 g glucose (Glucose), 30 g gelatin (Protein), or 50 g glucose with 30 g gelatin (Glucose + Protein) in water labeled with 150 mg [(13)C]acetate. Blood and breath samples were subsequently collected for 3 h to measure blood glucose and plasma insulin, glucagon-like peptide 1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) concentrations and gastric half-emptying time, which was calculated from (13)CO(2) excretion.<h4>Results</h4>The blood glucose response was less after Glucose + Protein than after Glucose (P < 0.005); GIP was lower (P < 0.005), and there were no significant differences in plasma insulin or GLP-1. Protein alone stimulated insulin, GLP-1, and GIP (P < 0.05 for each) without elevating blood glucose. The gastric half-emptying time was greater after Glucose + Protein than after Glucose (P < 0.05) and tended to be greater for Glucose than for Protein (P = 0.06).<h4>Conclusions</h4>In healthy humans, the addition of protein to oral glucose lowers postprandial blood glucose concentrations acutely, predominantly by slowing gastric emptying, although protein also stimulates incretin hormones and non-glucose-dependent insulin release. |
Keywords: | Humans Insulin Glucose Blood Glucose Dietary Proteins Administration, Oral Gastric Emptying Adult Male Glucagon-Like Peptide 1 Incretins |
Description: | © 2007 American Society for Nutrition |
DOI: | 10.1093/ajcn/86.5.1364 |
Published version: | http://www.ajcn.org/cgi/content/abstract/86/5/1364 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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