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https://hdl.handle.net/2440/41976
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dc.contributor.author | Chapman, I. | - |
dc.contributor.author | Parker, B. | - |
dc.contributor.author | Doran, S. | - |
dc.contributor.author | Feinle-Bisset, C. | - |
dc.contributor.author | Wishart, J. | - |
dc.contributor.author | Lush, C. | - |
dc.contributor.author | Chen, K. | - |
dc.contributor.author | LaCerte, C. | - |
dc.contributor.author | Burns, C. | - |
dc.contributor.author | McKay, R. | - |
dc.contributor.author | Weyer, C. | - |
dc.contributor.author | Horowitz, M. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Obesity, 2007; 15(5):1179-1186 | - |
dc.identifier.issn | 1930-7381 | - |
dc.identifier.issn | 1930-739X | - |
dc.identifier.uri | http://hdl.handle.net/2440/41976 | - |
dc.description.abstract | <h4>Objective</h4>We previously reported that a single preprandial injection (120 microg) of pramlintide, an analog of the beta-cell hormone amylin, reduced ad libitum food intake in obese subjects. To further characterize the meal-related effects of amylin signaling in humans, we studied a lower pramlintide dose (30 microg) in normal-weight subjects.<h4>Research methods and procedures</h4>In a randomized, double-blind, placebo-controlled, cross-over study, 15 healthy men (age, 24 +/- 7 years; BMI, 22.2 +/- 1.8 kg/m(2)) underwent a standardized buffet meal test on two occasions. After an overnight fast, subjects received a single subcutaneous injection of pramlintide (30 microg) or placebo, followed immediately by a standardized pre-load meal. After 1 hour, subjects were offered an ad libitum buffet meal, and total caloric intake and meal duration were measured.<h4>Results</h4>Compared with placebo, pramlintide reduced total caloric intake (1411 +/- 94 vs. 1190 +/- 117 kcal; Delta, -221 +/- 101 kcal; -14 +/- 9%; p = 0.05) and meal duration (36 +/- 2 vs. 31 +/- 3 minutes; Delta, -5.1 +/- 1.4 minutes; p < 0.005). Visual analog scale profiles of hunger trended lower and fullness higher during the first hour after pramlintide administration. In response to the buffet, hunger and fullness changed to a similar degree after pramlintide and placebo, despite subjects on pramlintide consuming 14% fewer kilocalories. Visual analog scale nausea ratings remained near baseline, without differences between treatments. Plasma peptide YY, cholecystokinin, and ghrelin concentrations did not differ with treatment, whereas glucagon-like peptide-1 concentrations after meals were lower in response to pramlintide than to placebo.<h4>Discussion</h4>These observations add support to the concept that amylin agonism may have a role in human appetite control. | - |
dc.description.statementofresponsibility | Ian Chapman, Barbara Parker, Selena Doran, Christine Feinle-Bisset, Judith Wishart, Cameron W. Lush, Kim Chen, Carl LaCerte, Colleen Burns, Robyn McKay, Christian Weyer and Michael Horowitz | - |
dc.language.iso | en | - |
dc.publisher | North Amer Assoc Study Obesity | - |
dc.source.uri | http://dx.doi.org/10.1038/oby.2007.626 | - |
dc.subject | peptide hormones | - |
dc.subject | buffet meal | - |
dc.subject | satiation | - |
dc.subject | hunger | - |
dc.subject | satiety | - |
dc.title | Low-dose pramlintide reduced food intake and meal duration in healthy, normal-weight subjects | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1038/oby.2007.626 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Feinle-Bisset, C. [0000-0001-6848-0125] | - |
dc.identifier.orcid | Horowitz, M. [0000-0002-0942-0306] | - |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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