Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/43004
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Embryo culture and long-term consequences |
Author: | Thompson, J. Mitchell, M. Kind, K. |
Citation: | Reproduction Fertility and Development, 2007; 19(1):43-52 |
Publisher: | C S I R O Publishing |
Issue Date: | 2007 |
ISSN: | 1031-3613 1448-5990 |
Statement of Responsibility: | Jeremy G. Thompson, Megan Mitchell and Karen L. Kind |
Abstract: | The development of pre-elongation (ruminants) and preimplantation (e.g. mouse and humans) embryos ex vivo has evolved over the past four decades into a reliable technology that is used as a research tool in developmental biology, as well as other embryo technologies, for application in infertility treatment, species conservation and selective breeding. It is clear from a variety of embryo culture studies that adaptive responses by embryos during culture can lead to significant alterations in subsequent developmental profiles, the mechanisms of which are not entirely clear but are unlikely to be limited to a single mechanism because this does not account for the variability seen in responses and the emerging list of specific cellular stressors that cause long-term deviations in fetal development. Epigenetic mechanisms, especially deviation of methylation patterns, and adaptation via causal pathways linking gene expression signalling with critical developmental time points, especially of placental development, are two candidates. Observational studies on post-transfer consequences must now be designed so that specific candidate pathways are followed to elucidate their role in perturbed development following transfer. |
Keywords: | Placenta Animals Cattle Humans Mice Culture Media Embryo Transfer Coculture Techniques Embryo Culture Techniques Adaptation, Physiological Epigenesis, Genetic Embryonic Development Fetal Development Pregnancy Quaternary Ammonium Compounds Female |
Description: | Copyright © 2007 IETS |
DOI: | 10.1071/RD06129 |
Published version: | http://www.publish.csiro.au/?act=view_file&file_id=RD06129.pdf |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.