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https://hdl.handle.net/2440/43077
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Type: | Journal article |
Title: | Expression of vascular endothelial growth factor (VEGF) in normal oral mucosa oral dysplasia and oral squamous cell carcinoma |
Author: | Johnstone, S. Logan, R. |
Citation: | International Journal of Oral and Maxillofacial Surgery, 2007; 36(3):263-266 |
Publisher: | Churchill Livingstone |
Issue Date: | 2007 |
ISSN: | 0901-5027 1399-0020 |
Statement of Responsibility: | S. Johnstone and R.M. Logan |
Abstract: | Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine implicated in tumour vasculogenesis. A significant increase in vascularity occurs during the transition from normal oral mucosa (NOM), through dysplasia, to squamous cell carcinoma (SCC). This study investigated the presence of VEGF in NOM, oral dysplasia and SCC. The correlation between VEGF expression and the grade of dysplasia or differentiation of SCC was also examined. Specimens consisting of NOM, oral dysplastic lesions and oral SCC were stained using standard immunohistochemistry methods to determine VEGF expression. Statistical analysis indicated an up-regulation of VEGF during the transition from NOM, through dysplasia to SCC. There was also a significant difference in expression according to differentiation of SCC, but not grade of dysplasia. As VEGF is a potent mediator of vascular development, these results suggest that VEGF may play an important role in the maintenance of a blood supply for developing pre-cancerous and invasive oral lesions. |
Keywords: | Mouth Mucosa Humans Carcinoma, Squamous Cell Mouth Neoplasms Cell Transformation, Neoplastic Neoplasm Invasiveness Precancerous Conditions Neovascularization, Pathologic Vascular Endothelial Growth Factor A Immunoenzyme Techniques Statistics, Nonparametric Case-Control Studies Cell Differentiation Up-Regulation Adult Aged Middle Aged Female Male |
Description: | Copyright © 2006 International Association of Oral and Maxillofacial Surgeons Published by Elsevier Ltd. |
DOI: | 10.1016/j.ijom.2006.09.017 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/623046/description#description |
Published version: | http://dx.doi.org/10.1016/j.ijom.2006.09.017 |
Appears in Collections: | Aurora harvest 6 Dentistry publications |
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