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https://hdl.handle.net/2440/43820
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Type: | Journal article |
Title: | Load-dependent effects of duodenal glucose on glycemia, gastrointestinal hormones, antropyloroduodenal motility, and energy intake in healthy men |
Author: | Pilichiewicz, A. Chaikomin, R. Brennan, I. Wishart, J. Rayner, C. Jones, K. Smout, A. Horowitz, M. Feinle-Bisset, C. |
Citation: | American Journal of Physiology: Endocrinology and Metabolism, 2007; 293(3):E743-E753 |
Publisher: | Amer Physiological Soc |
Issue Date: | 2007 |
ISSN: | 0193-1849 1522-1555 |
Statement of Responsibility: | Amelia N. Pilichiewicz, Reawika Chaikomin, Ixchel M. Brennan, Judith M. Wishart, Christopher K. Rayner, Karen L. Jones, Andre J. P. M. Smout, Michael Horowitz, and Christine Feinle-Bisset |
Abstract: | Gastric emptying is a major determinant of glycemia, gastrointestinal hormone release, and appetite. We determined the effects of different intraduodenal glucose loads on glycemia, insulinemia, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and cholecystokinin (CCK), antropyloroduodenal motility, and energy intake in healthy subjects. Blood glucose, plasma hormone, and antropyloroduodenal motor responses to 120-min intraduodenal infusions of glucose at 1) 1 ("G1"), 2) 2 ("G2"), and 3) 4 ("G4") kcal/min or of 4) saline ("control") were measured in 10 healthy males in double-blind, randomized fashion. Immediately after each infusion, energy intake at a buffet meal was quantified. Blood glucose rose in response to all glucose infusions (P < 0.05 vs. control), with the effect of G4 and G2 being greater than that of G1 (P < 0.05) but with no difference between G2 and G4. The rises in insulin, GLP-1, GIP, and CCK were related to the glucose load (r > 0.82, P < 0.05). All glucose infusions suppressed antral (P < 0.05), but only G4 decreased duodenal, pressure waves (P < 0.01), resulted in a sustained stimulation of basal pyloric pressure (P < 0.01), and decreased energy intake (P < 0.05). In conclusion, variations in duodenal glucose loads have differential effects on blood glucose, plasma insulin, GLP-1, GIP and CCK, antropyloroduodenal motility, and energy intake in healthy subjects. These observations have implications for strategies to minimize postprandial glycemic excursions in type 2 diabetes. |
Keywords: | Duodenum Pylorus Humans Insulin Resistance Hormones Insulin Glucose Energy Intake Gastrointestinal Motility Postprandial Period Adult Male |
Description: | Copyright © 2007 by the American Physiological Society. |
Provenance: | First published July 3, 2007 |
DOI: | 10.1152/ajpendo.00159.2007 |
Published version: | http://ajpendo.physiology.org/cgi/content/abstract/293/3/E743 |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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