Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/44000
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Type: Journal article
Title: Associations between high-density lipoprotein cholesterol and both stroke and coronary heart disease in the Asia Pacific region
Author: Woodward, M.
Barzi, F.
Feigin, V.
Gu, D.
Nakamura, K.
Patel, A.
Ho, S.
Jamrozik, K.
Citation: European Heart Journal, 2007; 28(21):2653-2660
Publisher: W B Saunders Co Ltd
Issue Date: 2007
ISSN: 0195-668X
1522-9645
Statement of
Responsibility: 
Mark Woodward, Federica Barzi, Valery Feigin, Dongfeng Gu, Rachel Huxley, Koshi Nakamura, Anushka Patel, Suzanne Ho, Konrad Jamrozik for the Asia Pacific Cohort Studies Collaboration
Abstract: Background: The inverse relationship between high-density lipoprotein (HDL) cholesterol and coronary heart disease (CHD) is well established. Questions remain about the association between HDL cholesterol and stroke, particularly for stroke subtypes. Methods and results: Cox survival models were applied to individual participant data from 25 cohort studies (about 80 000 subjects), with a median of 6.8 years follow-up. After adjustment for age and regression dilution, hazard ratios (95% confidence intervals) for a 1 standard deviation (SD) lower level of HDL cholesterol (0.4 mmol/L) were: for CHD events, 1.39 (1.22–1.57); for ischaemic stroke, 0.90 (0.75–1.07), and for haemorrhagic stroke, 0.89 (0.74–1.07). As total cholesterol (TC) increased relative to HDL cholesterol, the risk of CHD increased, the risk of ischaemic stroke was unchanged but the risk of haemorrhagic stroke decreased. A 1 SD increase in TC/HDL cholesterol (1.63 units) was associated with a 27% decrease in the risk of haemorrhagic stroke (95% confidence interval, 7–44%). Conclusion: There is clear evidence of potential benefit for CHD of increases in HDL cholesterol and decreases in TC relative to HDL cholesterol, but no evidence of an association between either HDL cholesterol or TC/HDL cholesterol and ischaemic stroke. Increasing HDL cholesterol relative to TC may increase the risk of haemorrhagic stroke.
Keywords: Cholesterol; Coronary disease; Stroke; Lipids
Rights: Copyright © 2008 European Society of Cardiology
RMID: 0020076548
DOI: 10.1093/eurheartj/ehm427
Appears in Collections:General Practice publications

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