Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/44352
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Type: Journal article
Title: Effects of fish-oil supplementation on myocardial fatty acids in humans
Author: Metcalf, R.
James, M.
Gibson, R.
Edwards, J.
Stubberfield, J.
Stuklis, R.
Roberts-Thomson, K.
Young, G.
Cleland, L.
Citation: American Journal of Clinical Nutrition, 2007; 85(5):1222-1228
Publisher: Amer Soc Clinical Nutrition
Issue Date: 2007
ISSN: 0002-9165
1938-3207
Statement of
Responsibility: 
Robert G Metcalf, Michael J James, Robert A Gibson, James RM Edwards, John Stubberfield, Robert Stuklis, Kurt Roberts-Thomson, Glenn D Young and Leslie G Cleland
Abstract: Increased fish or fish-oil consumption is associated with reduced risk of cardiac mortality, especially sudden death. This benefit putatively arises from the incorporation of the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into cardiomyocyte phospholipids.The study examined the kinetics of incorporation of n-3 fatty acids into human myocardial membrane phospholipids during supplementation with fish oil and alpha-linolenic acid-rich flaxseed oil.Patients with low self-reported fish intake (<1 fish meal/wk and no oil supplements) accepted for elective cardiac surgery involving cardiopulmonary bypass were randomly allocated to 1 of 6 groups: no supplement; fish oil (6 g EPA+DHA/d) for either 7, 14, or 21 d before surgery; flaxseed oil; or olive oil (both 10 mL/d for 21 d before surgery). Right atrial appendage tissue removed during surgery and blood collected at enrollment and before surgery were analyzed for phospholipid fatty acids.Surgery rescheduling resulted in a range of treatment times from 7 to 118 d. In the fish-oil-treated subjects, accumulation of EPA and DHA in the right atrium was curvilinear with time and reached a maximum at approximately 30 d of treatment and displaced mainly arachidonic acid. Flaxseed oil supplementation yielded a small increase in atrial EPA but not DHA, whereas olive oil did not significantly change atrial n-3 fatty acids.The results of the present study show that dietary n-3 fatty acids are rapidly incorporated into human myocardial phospholipids at the expense of arachidonic acid during high-dose fish-oil supplementation.
Keywords: Fish oils; fatty acids; n–3 fatty acids; dietary fats; myocardium; humans
Description: Copyright © 2007 by The American Society for Nutrition
RMID: 0020070805
DOI: 10.1093/ajcn/85.5.1222
Published version: http://www.ajcn.org/cgi/content/abstract/85/5/1222
Appears in Collections:Medicine publications

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