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https://hdl.handle.net/2440/44352
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dc.contributor.author | Metcalf, R. | - |
dc.contributor.author | James, M. | - |
dc.contributor.author | Gibson, R. | - |
dc.contributor.author | Edwards, J. | - |
dc.contributor.author | Stubberfield, J. | - |
dc.contributor.author | Stuklis, R. | - |
dc.contributor.author | Roberts-Thomson, K. | - |
dc.contributor.author | Young, G. | - |
dc.contributor.author | Cleland, L. | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | American Journal of Clinical Nutrition, 2007; 85(5):1222-1228 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.issn | 1938-3207 | - |
dc.identifier.uri | http://hdl.handle.net/2440/44352 | - |
dc.description | Copyright © 2007 by The American Society for Nutrition | - |
dc.description.abstract | <h4>Background</h4>Increased fish or fish-oil consumption is associated with reduced risk of cardiac mortality, especially sudden death. This benefit putatively arises from the incorporation of the long-chain n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into cardiomyocyte phospholipids.<h4>Objective</h4>The study examined the kinetics of incorporation of n-3 fatty acids into human myocardial membrane phospholipids during supplementation with fish oil and alpha-linolenic acid-rich flaxseed oil.<h4>Design</h4>Patients with low self-reported fish intake (<1 fish meal/wk and no oil supplements) accepted for elective cardiac surgery involving cardiopulmonary bypass were randomly allocated to 1 of 6 groups: no supplement; fish oil (6 g EPA+DHA/d) for either 7, 14, or 21 d before surgery; flaxseed oil; or olive oil (both 10 mL/d for 21 d before surgery). Right atrial appendage tissue removed during surgery and blood collected at enrollment and before surgery were analyzed for phospholipid fatty acids.<h4>Results</h4>Surgery rescheduling resulted in a range of treatment times from 7 to 118 d. In the fish-oil-treated subjects, accumulation of EPA and DHA in the right atrium was curvilinear with time and reached a maximum at approximately 30 d of treatment and displaced mainly arachidonic acid. Flaxseed oil supplementation yielded a small increase in atrial EPA but not DHA, whereas olive oil did not significantly change atrial n-3 fatty acids.<h4>Conclusion</h4>The results of the present study show that dietary n-3 fatty acids are rapidly incorporated into human myocardial phospholipids at the expense of arachidonic acid during high-dose fish-oil supplementation. | - |
dc.description.statementofresponsibility | Robert G Metcalf, Michael J James, Robert A Gibson, James RM Edwards, John Stubberfield, Robert Stuklis, Kurt Roberts-Thomson, Glenn D Young and Leslie G Cleland | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Clinical Nutrition | - |
dc.source.uri | http://www.ajcn.org/cgi/content/abstract/85/5/1222 | - |
dc.subject | Fish oils | - |
dc.subject | fatty acids | - |
dc.subject | n–3 fatty acids | - |
dc.subject | dietary fats | - |
dc.subject | myocardium | - |
dc.subject | humans | - |
dc.title | Effects of fish-oil supplementation on myocardial fatty acids in humans | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/ajcn/85.5.1222 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | James, M. [0000-0002-4918-2998] | - |
dc.identifier.orcid | Gibson, R. [0000-0002-8750-525X] | - |
Appears in Collections: | Aurora harvest 6 Medicine publications |
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