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|Title:||Is photosensitive epilepsy less common in males due to variation in X chromosome photopigment genes?|
|Citation:||Epilepsia, 2007; 48(9):1807-1809|
|Publisher:||Blackwell Publishing Inc|
|Isabella Taylor, Bree Hodgson, Ingrid E. Scheffer, John Mulley, Samuel F. Berkovic, Leanne Dibbens|
|Abstract:||Summary: Photosensitive epilepsy is less frequent among males than females. Red is the most epileptogenic color. The X-linked red pigment gene contains the polymorphism Ser180Ala; the Ser180 allele increases red sensitivity. We hypothesized that the paucity of males with photosensitive epilepsy is explained by the distribution of this sex-linked allele, and predicted photosensitive males would have a low frequency of this allele. We genotyped 35 males with photosensitive epilepsy and 84 male controls. Allele frequencies did not differ between these groups. The hypothesis was not supported, so alternate reasons for the sex bias in photosensitive epilepsy must be sought.|
|Keywords:||Chromosomes, Human, X; Humans; Epilepsy, Reflex; Genetic Predisposition to Disease; Retinal Pigments; Electroencephalography; Sex Factors; Sex Characteristics; Gene Frequency; Genotype; Polymorphism, Genetic; Australia; Male; Genes, X-Linked; Genetic Variation; Retinal Cone Photoreceptor Cells|
|Description:||The definitive version is available at www.blackwell-synergy.com|
|Appears in Collections:||Molecular and Biomedical Science publications|
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