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Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/45610
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dc.contributor.authorHo, L.-
dc.contributor.authorGaudieux, A.-
dc.contributor.authorFanok, S.-
dc.contributor.authorNewcombe, G.-
dc.contributor.authorHumpage, A.-
dc.date.issued2007-
dc.identifier.citationToxicon, 2007; 50(3):438-441-
dc.identifier.issn0041-0101-
dc.identifier.issn1879-3150-
dc.identifier.urihttp://hdl.handle.net/2440/45610-
dc.descriptionCopyright © 2007 Elsevier Ltd All rights reserved.-
dc.description.abstractMicrocystin-LR and -LA were readily biodegraded by a bacterium, Sphingpoyxis sp. LH21, in a treated reservoir water. Detection of the microcystins was conducted using high-performance liquid chromatography (HPLC), protein phosphatase 2A (PP2A) inhibition assay and a cell-based cytotoxicity assay. The HPLC results correlated well with the two assays. The decrease in cytotoxicity, coupled with the associated decrease in microcystin concentrations, indicated that no cytotoxic by-products were being generated, highlighting the applicability of biodegradation as a feasible treatment option for effective microcystin removal.-
dc.description.statementofresponsibilityLionel Ho, Anne-Laure Gaudieux, Stella Fanok, Gayle Newcombe and Andrew R. Humpage-
dc.description.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/259/description#description-
dc.language.isoen-
dc.publisherPergamon-Elsevier Science Ltd-
dc.source.urihttp://dx.doi.org/10.1016/j.toxicon.2007.03.021-
dc.subjectVero Cells-
dc.subjectAnimals-
dc.subjectAlphaproteobacteria-
dc.subjectWater-
dc.subjectBiodegradation, Environmental-
dc.subjectMicrocystins-
dc.subjectChlorocebus aethiops-
dc.titleBacterial degradation of microcystin toxins in drinking water eliminates their toxicity-
dc.typeJournal article-
dc.identifier.doi10.1016/j.toxicon.2007.03.021-
pubs.publication-statusPublished-
Appears in Collections:Aurora harvest 6
Environment Institute publications
Pharmacology publications

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