Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/47057
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Type: Journal article
Title: Systolic blood pressure diabetes and the risk of cardiovascular diseases in the Asia-Pacific region
Author: Kengne, A.
Patel, A.
Barzi, F.
Jamrozik, K.
Lam, T.
Ueshima, H.
Gu, D.
Suh, I.
Woodward, M.
Citation: Journal of Hypertension, 2007; 25(6):1205-1213
Publisher: Lippincott Williams & Wilkins
Issue Date: 2007
ISSN: 0263-6352
Statement of
Responsibility: 
Asia Pacific Cohort Studies Collaboration, Kengne AP, Patel A, Barzi F, Jamrozik K, Lam TH, Ueshima H, Gu DF, Suh I, Woodward M.
Abstract: OBJECTIVE: To assess the association between systolic blood pressure (SBP) and cardiovascular diseases (CVD) among participants with and without diabetes from cohorts in the Asia-Pacific region. RESEARCH DESIGN AND METHODS: Hazards ratios and 95% confidence intervals (CI) for CVD were calculated from Cox models, stratified by sex and region and adjusted for age using individual participant data from 36 cohort studies. Repeat measurements of SBP were used to adjust for regression dilution bias. RESULTS: During follow-up, 7387 fatal or non-fatal cardiovascular endpoints were recorded among 368 307 participants (6.4% with diabetes). SBP was associated with coronary heart disease (CHD), ischaemic stroke and haemorrhagic stroke in a continuous log-linear fashion among individuals with diabetes, as well as those without diabetes. Overall, each 10 mmHg higher usual SBP was associated with 18% (95% CI: 9-27%) and 23% (19-26%) greater risk for CHD among those with and without diabetes, respectively. The corresponding values for ischaemic stroke were 29% (14-45%) and 43% (37-50%), and for haemorrhagic stroke, 56% (32-83%) and 74% (66-82%). The test for heterogeneity by diabetes status in each of these associations was not significant (P >or= 0.10). CONCLUSIONS: Systolic blood pressure is an important marker of risk of CVD in people with and without diabetes. A given reduction in systolic blood pressure is likely to have a similar relative effect on reducing the risk of a cardiovascular event, regardless of diabetes status.
RMID: 0020081472
DOI: 10.1097/HJH.0b013e3280dce59e
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