Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/47139
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Type: Journal article
Title: Active and passive smoking and the risk of subarachnoid hemorrhage: An international population-based case-control study
Author: Anderson, C.
Feigin, V.
Bennett, D.
Lin, R.
Hankey, G.
Jamrozik, K.
Citation: Stroke, 2004; 35(3):633-637
Publisher: Lippincott Williams & Wilkins
Issue Date: 2004
ISSN: 0039-2499
1524-4628
Statement of
Responsibility: 
Craig S. Anderson; Valery Feigin; Derrick Bennett; Ruey-Bin Lin; Graeme Hankey; Konrad Jamrozik; for the Australasian Cooperative Research on Subarachnoid Hemorrhage Study (ACROSS) Group
Abstract: Background and Purpose— This study was undertaken to better clarify the risks associated with cigarette smoking and subarachnoid hemorrhage (SAH). Methods— The study included 432 incident cases of SAH frequency matched to 473 community SAH-free controls to determine dose-dependent associations of active and passive smoking (at home) and smoking cessation with SAH. Results— Compared with never smokers not exposed to passive smoking, the adjusted odds ratio for SAH among current smokers was 5.0 (95% confidence interval [CI], 3.1 to 8.1); for past smokers, 1.2 (95% CI, 0.8 to 2.0); and for passive smokers, 0.9 (95% CI, 0.6 to 1.5). Current and lifetime exposures showed a clear dose-dependent effect, and risks appeared more prominent in women and for aneurysmal SAH. Approximately 1 in 3 cases of SAH could be attributed to current smoking, but risks decline quickly after smoking cessation, even among heavy smokers. Conclusions— A strong positive association was found between cigarette smoking and SAH, especially for aneurysmal SAH and women, which is virtually eliminated within a few years of smoking cessation. Large opportunities exist for preventing SAH through smoking avoidance and cessation programs.
Keywords: case-control studies; epidemiology; intracranial aneurysm; smoking; subarachnoid hemorrhage
Rights: Copyright © 2004 American Heart Association
RMID: 0020081339
DOI: 10.1161/01.STR.0000115751.45473.48
Published version: http://stroke.ahajournals.org/cgi/content/abstract/35/3/633
Appears in Collections:Public Health publications

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