Adelaide Research & Scholarship
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https://hdl.handle.net/2440/47334
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| Type: | Journal article |
| Title: | B-vitamins reduce plasma levels of beta amyloid |
| Author: | Flickera, L. Martins, R. Thomas, J. Acres, J. Taddei, K. Vasikaran, S. Norman, P. Jamrozik, K. Almeida, O. |
| Citation: | Neurobiology of Aging, 2008; 29(2):303-305 |
| Publisher: | Elsevier Science Inc |
| Issue Date: | 2008 |
| ISSN: | 0197-4580 |
| Statement of Responsibility: | Leon Flicker, Ralph N. Martins, Jenny Thomas, John Acres, Kevin Taddei, Samuel D. Vasikaran, Paul Norman, Konrad Jamrozik, Osvaldo P. Almeida |
| Abstract: | Elevated plasma homocysteine (tHcy) is a risk factor for Alzheimer's disease (AD), and thus B vitamins may have a role in the prevention of AD. The objective of this study was to determine if tHcy lowering vitamins decrease the circulating levels of A-beta protein 1–40 (Aβ40). We randomized 299 older men to treatment with 2 mg of folate, plus 25 mg of B6 and 400 μg of B12, or placebo. After 2 years of treatment the mean (S.E.) increase of Aβ40 was 7.0 pg/ml (8.4) in the vitamin group (4.9%), and 26.8 pg/ml (7.7) (18.5%) in the placebo group. We conclude that B vitamins may decrease the plasma level of Aβ40 and have a role in the prevention of AD. |
| DOI: | 10.1016/j.neurobiolaging.2006.10.007 |
| Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/525480/description#description |
| Published version: | http://dx.doi.org/10.1016/j.neurobiolaging.2006.10.007 |
| Appears in Collections: | Aurora harvest 6 General Practice publications |
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