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https://hdl.handle.net/2440/4836
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Type: | Journal article |
Title: | Backbone cleavages of [M - H]- anions derived from caerin 1 peptides and some synthetic modifications. Molecular recognition initiating internal cyclisation of Glu23 |
Author: | Brinkworth, C. Bowie, J. |
Citation: | Rapid Communications in Mass Spectrometry, 2002; 16(14):1339-1351 |
Publisher: | John Wiley & Sons Ltd |
Issue Date: | 2002 |
ISSN: | 0951-4198 1097-0231 |
Statement of Responsibility: | Craig S. Brinkworth, John H. Bowie |
Abstract: | The collision induced spectra of [M - H](-) anions from of caerin 1 peptides and some synthetic modifications show the usual alpha, beta and beta' backbone cleavages together with Ser (epsilon,gamma) and Glu (gamma) cleavages which break the peptide backbone in the vicinity of those residues. All of these cleavages require the peptide backbone to be flexible. There is also a backbone cleavage of a type not observed before. This cleavage involves nucleophilic attack of the carboxylate anion of the Glu23 side chain at the backbone CH of Ile 21. We propose that this cleavage requires the caerin peptide to be in an alpha helical conformation (the 3D structure that this peptide adopts in solution) in order that the interacting groups are held in close proximity. |
Keywords: | Animals Anions Glutamic Acid Antimicrobial Cationic Peptides Peptide Fragments Amphibian Proteins Spectrometry, Mass, Fast Atom Bombardment Molecular Structure Amino Acid Sequence Protein Structure, Secondary Cyclization Models, Molecular Molecular Sequence Data Amphibians |
Description: | The definitive version may be found at www.wiley.com |
Provenance: | Published Online: 12 Jun 2002 |
DOI: | 10.1002/rcm.719 |
Published version: | http://www3.interscience.wiley.com/journal/94517472/abstract |
Appears in Collections: | Aurora harvest 2 Chemistry publications |
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