Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/51206
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | The effect of weight loss on anti-Müllerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment |
Other Titles: | The effect of weight loss on anti-Mullerian hormone levels in overweight and obese women with polycystic ovary syndrome and reproductive impairment |
Author: | Thomson, R. Buckley, J. Moran, L. Noakes, M. Clifton, P. Norman, R. Brinkworth, G. |
Citation: | Human Reproduction, 2009; 24(8):1976-1981 |
Publisher: | Oxford Univ Press |
Issue Date: | 2009 |
ISSN: | 0268-1161 1460-2350 |
Statement of Responsibility: | R.L. Thomson, J.D. Buckley, L.J. Moran, M. Noakes, P.M. Clifton, R.J. Norman and G.D. Brinkworth |
Abstract: | <h4>Background</h4>Anti-Müllerian hormone (AMH) has been proposed as a clinical predictor of improvements in reproductive function following weight loss in overweight and obese women with polycystic ovary syndrome (PCOS). This study aimed to assess whether baseline and/or change in AMH levels with weight loss predict improvements in reproductive function in overweight and obese women with PCOS.<h4>Methods</h4>Fifty-two overweight and obese women with PCOS and reproductive impairment (age 29.8 +/- 0.8 years, BMI 36.5 +/- 0.7 kg/m(2)) followed a 20-week weight loss programme. AMH, weight, menstrual cyclicity and ovulatory function were assessed at baseline and post-intervention.<h4>Results</h4>Participants who responded with improvements in reproductive function (n = 26) had lower baseline AMH levels (23.5 +/- 3.7 versus 32.5 +/- 2.9 pmol/l; P = 0.03) and experienced greater weight loss (-11.7 +/- 1.2 versus -6.4 +/- 0.9 kg; P = 0.001) compared with those who did not respond (n = 26). Logistic regression analysis showed that weight loss and baseline AMH were independently related to improvements in reproductive function (P = 0.002 and P = 0.013, respectively). AMH levels did not change with weight loss in both responders and non-responders.<h4>Conclusions</h4>In overweight and obese women with PCOS and reproductive dysfunction, a 20-week weight loss intervention resulted in improvements in reproductive function but no change in AMH levels.<h4>Clinical trials registration number</h4>ACTRN12606000198527. |
Keywords: | weight loss anti-Müllerian hormone reproductive function menstrual cyclicity |
DOI: | 10.1093/humrep/dep101 |
Published version: | http://dx.doi.org/10.1093/humrep/dep101 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.