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https://hdl.handle.net/2440/51333
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Type: | Journal article |
Title: | Obesity and testicular function |
Author: | Mah, P. Wittert, G. |
Citation: | Molecular and Cellular Endocrinology, 2010; 316(2 Sp Iss):180-186 |
Publisher: | Elsevier Sci Ireland Ltd |
Issue Date: | 2010 |
ISSN: | 0303-7207 1872-8057 |
Statement of Responsibility: | P.M. Mah and G.A. Wittert |
Abstract: | Obesity in men, particularly when central, is associated with lower total testosterone [TT], free testosterone [FT] and sex hormone-binding globulin [SHBG], and a greater decline in TT and FT with increasing age compared with lean men. Obesity-related conditions such as obstructive sleep apnea, insulin resistance and type 2 diabetes mellitus are independently associated with decreased plasma testosterone. Possible mechanisms include decreased LH pulse amplitude, inhibitory effects of oestrogen at the hypothalamus and pituitary and the effects of leptin and other peptides centrally and on Leydig cells. Obese men have reduced sperm concentration and total sperm count compared to lean men but sperm motility and morphology appear unaffected. The cause and effect relationships between low plasma androgen levels, obesity and the metabolic syndrome, and associated cardiometabolic risk remain unclear. While weight loss normalizes TT and FT in obese men, androgen replacement in the short term does not significantly improve cardiometabolic risk profile despite reducing fat mass. |
Keywords: | Obesity Testosterone Sex hormone-binding globulin Insulin resistance Spermatogenesis |
Description: | First published online in 2009 |
Rights: | Copyright © 2009 Elsevier Ireland Ltd All rights reserved. |
DOI: | 10.1016/j.mce.2009.06.007 |
Published version: | http://dx.doi.org/10.1016/j.mce.2009.06.007 |
Appears in Collections: | Aurora harvest Medicine publications |
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