Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/51787
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Type: Journal article
Title: Periodontal ligament stem cell-mediated treatment for periodontitis in miniature swine
Author: Liu, Y.
Zheng, Y.
Ding, G.
Fang, D.
Zhang, C.
Bartold, P.
Gronthos, S.
Shi, S.
Wang, S.
Citation: Stem Cells, 2008; 26(4):1065-1073
Publisher: Alphamed Press
Issue Date: 2008
ISSN: 1066-5099
1549-4918
Statement of
Responsibility: 
Yi Liu, Ying Zheng, Gang Ding, Dianji Fang, Chunmei Zhang, Peter Mark Bartold, Stan Gronthos, Songtao Shi and Songlin Wang
Abstract: Periodontitis is a periodontal tissue infectious disease and the most common cause for tooth loss in adults. It has been linked to many systemic disorders, such as coronary artery disease, stroke, and diabetes. At present, there is no ideal therapeutic approach to cure periodontitis and achieve optimal periodontal tissue regeneration. In this study, we explored the potential of using autologous periodontal ligament stem cells (PDLSCs) to treat periodontal defects in a porcine model of periodontitis. The periodontal lesion was generated in the first molars area of miniature pigs by the surgical removal of bone and subsequent silk ligament suture around the cervical portion of the tooth. Autologous PDLSCs were obtained from extracted teeth of the miniature pigs and then expanded ex vivo to enrich PDLSC numbers. When transplanted into the surgically created periodontal defect areas, PDLSCs were capable of regenerating periodontal tissues, leading to a favorable treatment for periodontitis. This study demonstrates the feasibility of using stem cell-mediated tissue engineering to treat periodontal diseases.
Keywords: Cells, Cultured; Stem Cells; Periodontal Ligament; Animals; Swine; Swine, Miniature; Periodontitis; Disease Models, Animal; Treatment Outcome; Stem Cell Transplantation
Description: The definitive version may be found at www.wiley.com
RMID: 0020080546
DOI: 10.1634/stemcells.2007-0734
Appears in Collections:Dentistry publications

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