Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/51867
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Type: Journal article
Title: Homocysteine and C-reactive protein are not markers of cognitive impairment in patients with major cardiovascular disease
Author: Silbert, B.
Evered, L.
Scott, D.
McCutcheon, C.
Jamrozik, K.
Citation: Dementia and Geriatric Cognitive Disorders, 2008; 25(4):309-316
Publisher: Karger
Issue Date: 2008
ISSN: 1420-8008
1421-9824
Statement of
Responsibility: 
Brendan Silbert, Lisbeth Evered, David A. Scott, Craig McCutcheon and Konrad Jamrozik
Abstract: BACKGROUND: Raised concentrations of plasma homocysteine and C-reactive protein (CRP) are associated with vascular disease and have also been implicated as independent risk factors for cognitive impairment in population studies. OBJECTIVES: To investigate the association of plasma homocysteine and CRP with cognition in patients scheduled for coronary artery bypass graft (CABG) surgery. Cognition was assessed in 264 patients using a standard battery of neuropsychological tests. Patients were classified as having preexisting cognitive impairment (PreCI) by reference to a healthy control group or postoperative cognitive dysfunction (POCD) by reference to baseline test scores. RESULTS: PreCI was present in 37.3% of patients, and POCD was present in 18.3, 12.1 and 13.6% of patients at 1 week, 3 months and 12 months postoperatively. On multivariate analysis neither homocysteine nor CRP were independently associated with cognition at any testing time but were strongly associated with age and left ventricular function. CONCLUSION: PreCI and POCD are present in a substantial proportion of patients undergoing CABG surgery but there is no independent association with either baseline homocysteine or CRP levels. It is possible that cognitive impairment may result from the vascular disease rather than a direct association with either homocysteine or CRP.
Keywords: Homocysteine; C-reactive protein; Cognitive impairment; Cardiovascular disease
Description: Copyright © 2008 S. Karger AG, Basel
RMID: 0020080530
DOI: 10.1159/000119105
Appears in Collections:Public Health publications

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