Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/52160
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dc.contributor.authorParida, L.-
dc.contributor.authorMele, M.-
dc.contributor.authorCalafell, F.-
dc.contributor.authorBertranpetit, J.-
dc.contributor.authorSchurr, T.-
dc.contributor.authorSantos, F.-
dc.contributor.authorQuintana-Murci, L.-
dc.contributor.authorComas, D.-
dc.contributor.authorTyler-Smith, C.-
dc.contributor.authorZalloua, P.-
dc.contributor.authorBalanovska, E.-
dc.contributor.authorBalanovsky, O.-
dc.contributor.authorBehar, D.-
dc.contributor.authorMitchell, R.-
dc.contributor.authorJin, L.-
dc.contributor.authorSoodyall, H.-
dc.contributor.authorPitchappan, R.-
dc.contributor.authorCooper, A.-
dc.contributor.authorRoyyuru, A.-
dc.contributor.authorRosset, S.-
dc.contributor.authoret al.-
dc.contributor.otherCooper, Alan-
dc.date.issued2008-
dc.identifier.citationJournal of Computational Biology, 2008; 15(9):1133-1153-
dc.identifier.issn1066-5277-
dc.identifier.issn1557-8666-
dc.identifier.urihttp://hdl.handle.net/2440/52160-
dc.descriptionCopyright © Mary Ann Liebert, Inc. University of Adelaide consortium member: Alan Cooper-
dc.description.abstractTraditionally nonrecombinant genome, i.e., mtDNA or Y chromosome, has been used for phylogeography, notably for ease of analysis. The topology of the phylogeny structure in this case is an acyclic graph, which is often a tree, is easy to comprehend and is somewhat easy to infer. However, recombination is an undeniable genetic fact for most part of the genome. Driven by the need for a more complete analysis, we address the problem of estimating the ancestral recombination graph (ARG) from a collection of extant sequences. We exploit the coherence that is observed in the human haplotypes as patterns and present a network model of patterns to reconstruct the ARG. We test our model on simulations that closely mimic the observed haplotypes and observe promising results.-
dc.description.statementofresponsibilityLaxmi Parida, Marta Mele, Francesc Calafell, Jaume Bertranpetit and The Genographic Consortium-
dc.language.isoen-
dc.publisherMary Ann Liebert Inc Publ-
dc.source.urihttp://dx.doi.org/10.1089/cmb.2008.0065-
dc.subjectGenographic Consortium-
dc.subjectChromosomes, Human, Y-
dc.subjectHumans-
dc.subjectDNA, Mitochondrial-
dc.subjectPhylogeny-
dc.subjectRecombination, Genetic-
dc.subjectHaplotypes-
dc.subjectPolymorphism, Single Nucleotide-
dc.subjectMultigene Family-
dc.subjectAlgorithms-
dc.subjectModels, Genetic-
dc.titleEstimating the ancestral recombinations graph (ARG) as compatible networks of SNP patterns-
dc.typeJournal article-
dc.identifier.doi10.1089/cmb.2008.0065-
pubs.publication-statusPublished-
dc.identifier.orcidCooper, A. [0000-0002-7738-7851]-
Appears in Collections:Aurora harvest
Australian Centre for Ancient DNA publications
Earth and Environmental Sciences publications
Environment Institute Leaders publications

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